Results 51 to 60 of about 19,940,452 (132)

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Aging Cell, Volume 25, Issue 10, October 2026.
Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we demonstrate that EVs within the SASP are necessary and sufficient to induce paracrine senescence.
Valentin Estevez‐Souto, Alex Miralles‐Dominguez, Pablo Pedrosa, Patricia Lado‐Fernandez, Miguel A. Prados, Alejandro Failde‐Fiestras, Raquel Paredes‐Paredes, Jorge Ruz‐Ortega, Maria J. Alonso, Martina Migliavacca, Ester Polo, Rebeca Alvarez‐Velez, Enrique Vazquez de Luis, Ana Dopazo, Gabriela N. Condezo, Carmen San Martin, Miguel Gonzalez‐Barcia, Ramón Lobato‐Busto, Pilar Ximénez‐Embún, Javier Muñoz, Manuel Collado, Sabela Da Silva‐Alvarez   +21 more
wiley   +1 more source

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells [PDF]

, 2010
We have previously reported that deletion of the retinoblastoma gene Rb leads to rapid but transient p53 stabilisation. We investigated here the pathways involved.
Bellamy, Christopher, Harrison, David J, Treanor, Louise, Prost, Sandrine, Harrison, David J.   +4 more
core   +1 more source

ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]

, 2004
Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core   +1 more source

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
wiley   +1 more source

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
PRAME promotes SACC invasion and metastasis by inducing EMT via Twist1 upregulation and by destabilizing RARα through Cullin2‑mediated ubiquitination, a mechanism that may limit ATRA efficacy. In vivo, PRAME enhances subcutaneous growth and lung metastasis, highlighting its oncogenic role in SACC.
Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen   +8 more
wiley   +1 more source

The mechanisms of regulation of Hdm2 protein level by serum growth factors [PDF]

, 2006
Cell cycle progression in response to serum growth factors is dependent on the expression of functional Hdm2 (Mdm2), which inhibits p53-dependent transcription of anti-proliferative genes.
Blaydes, Jeremy P., Chris J. Jones, Jones, Chris J., Phillips, Anna, Jeremy P. Blaydes, Anna Phillips   +5 more
core   +1 more source

A Giant Fat‐Containing Lesion of the Terminal Ileum: Imaging‐Guided Surgical Management

ANZ Journal of Surgery, EarlyView.
Eddy Traversari, Raissa De Oliveira Aquino Schuffner, Jérôme Guiramand, Jacques‐Emmanuel Saadoun   +3 more
wiley   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source