Results 61 to 70 of about 19,940,452 (132)
C/EBPalpha downregualtes c-jun expression [PDF]
, 2003 The transcription factor C/EBPa is crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells.
Rangatia, Janki
core +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product
, 1983 Organisms amenable to easy genetic analysis should prove helpful in assessing the function of at least those proto-oncogene products which are highly conserved in different eukaryotic cells.
Sander, C., Donath, C., Gallwitz, D.
core +1 more source
Gene Expression in Neuroblastoma [PDF]
, 1996 The aim of this project is to identify potential target genes (NTG's) which may be regulated by in the cell line SK-N-SH which has no amplification of theoncogene N-myc.
Said, Sohair S.S.
core
Gene mutations and expression in breast cancer [PDF]
, 2000 Bibliography: leaves 163-190.Breast cancer is the most common cause of death amongst women, with the incidence of the disease varying between countries. Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour
Donninger, Howard
core +1 more source
The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1 [PDF]
, 2003 Verschiedene Transkriptionsfaktoren spielen eine Rolle in der Entwicklung myeloischer Zellen. PU.1, ein Transkriptionsfaktor aus der ETS-Familie, ist sowohl für die Entwicklung lymphatischer als auch für die Entwicklung myeloischer Zellen von Bedeutung ...
Reddy, Venkateshwar
core +1 more source
The role of oncogenic Cbl mutants in Kit signaling and myeloid transformation [PDF]
, 2010 Acute myeloid leukemia (AML) is a hematopoietic cell disorder characterized by a block in differentiation and increased proliferation and survival of malignant blasts. Expansion of the malignant cell clone effects the normal production of blood cells and
Bandi, Srinivasa Rao
core
Investigation of the intrinsic mechanism of drug resistance in multiple myeloma [PDF]
, 2011 The focus of this thesis was to evaluate the mechanisms whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment.
Ooi, Melissa
core
Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]
The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
core
, 2007 在許多癌症中均發現MDM2(mouse double minute 2)基因有過量表現之情形，這是因為MDM2基因可以抑制腫瘤抑制基因p53的表現量。除此以外，目前的研究也發現MDM2可以參與其他獨立於p53的功能，其在細胞週期調控、分化、細胞命運的決定、DNA的修補、基本轉錄調控及其他方面的功能上均扮演重要角色。此外，在不同的模式動物如轉殖鼠、果蠅跟斑馬魚之研究顯示過量表現MDM2會抑制生長及影響細胞分化。因此本實驗中我們利用肝臟發綠螢光的轉基因斑馬魚 ...
Huang, Shin-Jie, 黃信傑
core