Results 121 to 130 of about 45,592 (164)

Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers

MedComm, Volume 7, Issue 2, February 2026.
The BRAF25 meta‐signature effectively captures BRAF‐driven oncogenic activity. By enabling precise patient stratification with distinct mutation profiles, BRAF25 identifies BRAF‐active tumor subtypes and provides superior prognostic value compared with mutation status alone.
Kaidi Yang, Shihui Fu, Jingbing Liang, Lijuan Ding, Junhao You, Fang Li, Ye Yuan, Xiu‐Wu Bian   +7 more
wiley   +1 more source

MET and SLFN11 as a Players in the SCLC Molecular Subtyping Game. [PDF]

Int J Mol Sci
Grenda A, Galant N, Łomża-Łaba A, Krawczyk P, Jankowski T, Chmielewska I, Szczyrek M, Kieszko R, Milanowski J.   +8 more
europepmc   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Improvement of Diagnostics in NSCLC Patients with <i>MET</i> Exon 14 Mutations Using Complementary DNA/RNA-NGS and Identification of Two Novel Exonic Splicing Mutations. [PDF]

Int J Mol Sci
Urbanska EM, Doktor TK, Melchior LC, Petersson ES, Sørensen JB, Santoni-Rugiu E, Andresen BS, Grauslund M.   +7 more
europepmc   +1 more source

Spatial analysis of HPV‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

The Journal of Pathology, Volume 268, Issue 2, Page 200-214, February 2026.
Abstract Cervical cancer remains the fourth most common cancer affecting women worldwide, and incidences of other HPV‐related cancers continue to rise. For the development of effective prevention strategies in high‐risk patients, we aimed to better understand the roles of inflammatory pathways and the tumour microenvironment as the main driver of ...
Gianna Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O'Brien, Michael Walsh, Andrew Causer, Janin Chandra, Quan Nguyen, Ian H Frazer   +9 more
wiley   +1 more source

MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression. [PDF]

Front Oncol
Tirpe AA, Nutu A, Busuioc C, Pop OL, Berindan-Neagoe I.   +4 more
europepmc   +1 more source

Molecular alterations in high‐grade neuroendocrine tumors of the small intestine

The Journal of Pathology, Volume 268, Issue 2, Page 215-226, February 2026.
Abstract High‐grade neuroendocrine tumors of the small intestine are separated into two groups: well‐differentiated neuroendocrine tumors (NETs, high‐grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entities, with few molecular data available, and are very challenging to treat.
Agathe Hercent, Julien Masliah‐Planchon, David Cohen, Remy Nicolle, Jean‐Yves Scoazec, Philippe Ruszniewski, Ivan Bièche, Louis de Mestier, Anne Couvelard, Jerome Cros   +9 more
wiley   +1 more source

Advances in Targeted Therapy for Non-Small-Cell Lung Cancer: Current Progress and Future Directions. [PDF]

Int J Mol Sci
Peshin S, Takrori E, Yazji JH, Haque J, Dharia A, Mithani MS, Anum F, Asfeen U, Couch JK, Donovan M, Singal S.   +10 more
europepmc   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Circular RNA circ_0001591 Contributes to Melanoma Cell Migration Through AXL and FRA1 Proteins by Targeting miR-20a-3p and miR-34a-5p. [PDF]

Genes (Basel)
Orlandi E, De Tomi E, Belpinati F, Menegazzi M, Gomez-Lira M, Romanelli MG, Trabetti E.   +6 more
europepmc   +1 more source