Results 121 to 130 of about 49,807 (253)
Wilms Tumor in Children with AMER1/WTX Germline Pathogenic Variants: A Multicenter Case Series
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 10–15% of children with Wilms tumor (WT) have predisposing genetic syndromes. Somatic mutations are frequently identified; however, germline pathogenic variants in AMER1 are much less prevalent and are associated with osteopathia striata with cranial sclerosis (OSCS).
Insiyah Campwala +9 more
wiley +1 more source
Precision Medical Sciences, EarlyView.Predicting the significance of expressions of MALAT and UCA1 lncRNAs in patients with glioblastoma multiform. Abstract Glioblastoma multiforme (GBM) is a common central nervous system malignancy with poor survival despite new treatments. Although some evidence demonstrated the prognostic effects of metastasis‐associated lung adenocarcinoma transcript 1
Sedighe Hooshmandi +12 more
wiley +1 more source
Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma
Small Science, EarlyView.This review critically evaluates current state‐of‐the‐art in vitro glioma models especially glioma‐on‐a‐chip models based on readout capability, performance, and physiological relevance. It summarizes the key parameters and proposes a practical framework to guide researchers in selecting the most suitable preclinical models for glioma studies.
Su Liu +5 more
wiley +1 more source
Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
Small Methods, EarlyView.The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu +6 more
wiley +1 more source
Small Methods, EarlyView.This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta +7 more
wiley +1 more source
VIEW, EarlyView.Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding +10 more
wiley +1 more source
Gene structure of the human receptor tyrosine kinase Ron and mutation analysis in lung cancer samples. [PDF]
, 2000 ANGELONI, DEBORA +6 more
core +1 more source
Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
FASEB BioAdvances, EarlyView.Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn +5 more
wiley +1 more source
Aging Cell, EarlyView.Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers +16 more
wiley +1 more source
Aging Cell, EarlyView.Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray +10 more
wiley +1 more source