Results 131 to 140 of about 45,592 (164)

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Renal cell carcinoma (RCC) presents a significant global health challenge, with a substantial proportion of patients diagnosed with advanced or metastatic disease due to the limitations of current diagnostic imaging and the lack of validated non‐invasive biomarkers.
Hossam Kamli, Najeeb Ullah Khan
wiley   +1 more source

Response to dabrafenib and trametinib combined with pembrolizumab in an elderly patient with lung adenocarcinoma of unknown primary harboring BRAF V600E mutation and high PD-L1 expression: a case report. [PDF]

Front Immunol
Li N, Hu J, Bao G, Cai Z.
europepmc   +1 more source

ETS Variant Transcription Factor 6 Promotes Glucose Metabolism Reprogramming in HCC

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Glucose metabolic reprogramming is a key hallmark of tumour cells, and the designed inhibitors targeting tumour glucose metabolism reprogramming may serve as an effective therapeutic strategy. The ETS Variant Transcription Factor 6 (ETV6) is a potent transcriptional repressor strongly associated with tumorgenesis. However, the precise role and
Chunmei Guo, Lingqian Xie, Huiqing Yin, Lina Yi, Lin Jin, Xiangwei Liu, Qingqing Zhang, Zijian Li, Shuqing Liu, Ming‐Zhong Sun   +9 more
wiley   +1 more source

Detection of KRAS, NRAS and BRAF Mutations in Liquid Biopsy from Patients with Colorectal Cancer. [PDF]

Oncol Res
Ondraskova K, Cwik M, Horky O, Berkovcova J, Holcakova J, Bartosik M, Kazda T, Mrazova K, Uher M, Kiss I, Hrstka R.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

An overview of mechanisms, biomarkers, and treatment strategies for acquired anti-EGFR resistance in RAS wild-type colorectal cancer. [PDF]

Front Pharmacol
Ding C, Yao R, Wang Y, Liu H, Li C, Xie H.   +5 more
europepmc   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications. [PDF]

Cancer Med
Zhang Y, Luo N, Ge M, Zhang Y, Chen D, Li Y.   +5 more
europepmc   +1 more source

Sex differences in the clinical presentation of patients with newly diagnosed multiple myeloma

Cancer, Volume 132, Issue 2, 15 January 2026.
Abstract Introduction Standardized incidence rates of multiple myeloma (MM) are higher among males than females, suggesting that male sex is an important risk factor for MM, which may affect disease etiology, pathogenesis, and clinical presentation. Methods The association of sex with the prevalence of clinical features and chromosomal abnormalities ...
Krystle L. Ong, Kevin D. Arnold, Meredith C. Wessel, Gayatri Ravi, Faith E. Davies, Gareth J. Morgan, Elizabeth E. Brown   +6 more
wiley   +1 more source