Results 131 to 140 of about 49,807 (253)
“Misuse” of RNA‐seq data in microbiome studies: A cautionary tale of poly(A)
mLife, EarlyView.
John Maringa Githaka
wiley +1 more source
Objectives To provide the first comprehensive molecular characterisation of penile intraepithelial neoplasia (PeIN) and to define the molecular alterations and clinical parameters associated with recurrence in order to enhance our ability to manage this disease.
Sara Kaczor Elbæk+6 more
wiley +1 more source
Abstract Background and Purpose Immune checkpoint inhibitors, such as antiPD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács+13 more
wiley +1 more source
We established a novel patient‐derived BRAF V600E‐mutated lung adenocarcinoma cell line and demonstrated that combining a novel TEAD1 inhibitor (VT103) with dabrafenib enhances therapeutic efficacy through survivin downregulation. Our tissue microarray analysis revealed a strong correlation between YAP1, TEAD1, and survivin expression in lung ...
Kazutaka Hosoya+19 more
wiley +1 more source
Oncogenic gene fusions in cancer: from biology to therapy. [PDF]
Liu SV+4 more
europepmc +1 more source
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou+5 more
wiley +1 more source
Crizotinib Inhibits Viability, Migration, and Invasion by Suppressing the <i>c-Met</i>/<i>PI3K</i>/<i>Akt</i> Pathway in the Three-Dimensional Bladder Cancer Spheroid Model. [PDF]
Song B, Kim D, Ho JN, Le VH, Lee S.
europepmc +1 more source
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng+10 more
wiley +1 more source
AXL and SRC in clear cell renal cell carcinoma: absence of mutations, rare alternative splicing events, but association of protein expression with poor prognosis. [PDF]
Brada MD+7 more
europepmc +1 more source
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun+5 more
wiley +1 more source