Results 141 to 150 of about 49,807 (253)

MicroRNAs as Sensitizers of Tyrosine Kinase Inhibitor Resistance in Cancer: Small Molecule Partnerships. [PDF]

Pharmaceuticals (Basel)
Campos-Parra AD, Sánchez-Marín D, Acevedo-Sánchez V.   +2 more
europepmc   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

B7-H3 and c-MET in advanced prostate cancer: exploring possibilities of novel bi-specific drug development. [PDF]

Eur J Med Res
He W, Li H, Sun W, Zhang Y, Wu, Ao C, Wang J, Yang Y, Xiao X, Zhang L, Yue J, Wang X.   +11 more
europepmc   +1 more source

Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock

The FEBS Journal, EarlyView.
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány, Anita Szőke, Aladár Pettkó‐Szandtner, Eszter Éva Kálmán, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +6 more
wiley   +1 more source

Dramatic response to crizotinib through MET phosphorylation inhibition in rare TFG-MET fusion advanced squamous cell lung cancer. [PDF]

Oncologist
Cheng W, Xu T, Yang L, Yan N, Yang J, Fang S.   +5 more
europepmc   +1 more source

Correlating p53 immunostaining patterns with somatic TP53 mutation and functional properties of mutant p53 in triple‐negative breast cancer

Histopathology, EarlyView.
This study introduces newly defined criteria for interpreting p53 IHC expression in triple‐negative breast cancer. These criteria could enable the prediction of TP53 mutation types and their functional implications, providing valuable insights for future clinical research and potentially improving stratification of treatment options for patients.
Meejeong Kim, Miseon Lee, Ahwon Lee, Byung‐Ock Choi, Woo‐Chan Park, Sung Hun Kim, Jieun Lee, Jun Kang   +7 more
wiley   +1 more source

Targeting c-MET Alterations in Cancer: A Review of Genetic Drivers and Therapeutic Implications. [PDF]

Cancers (Basel)
Ji M, Ganesan S, Xia B, Huo Y.
europepmc   +1 more source

Mechanistic insights into dental stem cells‐derived exosomes in regenerative endodontics

International Endodontic Journal, EarlyView.
Abstract Background Dental pulp is a richly vascularised and innervated tissue vital for tooth vitality, sensory function, and structural integrity. While conventional root canal therapy effectively treats necrotic permanent teeth, it irreversibly eliminates pulp vitality, potentially increasing the risk of secondary infections and long‐term structural
Paras Ahmad, Nathan Estrin, Nima Farshidfar, Yufeng Zhang, Richard J. Miron   +4 more
wiley   +1 more source

Novel <i>EVI5</i>::<i>BRAF</i> Gene Fusion in Infantile Fibrosarcoma: A Case Report and Review of Literature. [PDF]

Int J Mol Sci
González-López J, Rubio-Martínez LA, Atarés M, Amaya JV, Huart MC, Mayordomo-Aranda E, Giner F.   +6 more
europepmc   +1 more source

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

International Journal of Dermatology, EarlyView.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves   +3 more
wiley   +1 more source