Results 161 to 170 of about 49,807 (253)

A clinically feasible multiplex proteomic immunoassay as a novel functional diagnostic for pancreatic ductal adenocarcinoma [PDF]

, 2017
Azar, Riad R, Cao, Dengfeng, Early, Dayna S, et al,, Gao, Feng, Kushnir, Vladamir M, Li, Lin, Lim, Kian-Huat, Luo, Jingqin, Mullady, Daniel K, Wang-Gillam, Andrea   +10 more
core   +2 more sources

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Prolonged complete response to adjuvant tepotinib in a patient with newly diagnosed disseminated glioblastoma harboring mesenchymal-epithelial transition fusion. [PDF]

Oncologist
Pham LC, Weller L, Gann CN, Schumacher KM, Vlassak S, Swanson T, Highsmith K, O'Brien BJ, Nash S, Aaroe A, de Groot JF, Majd NK.   +11 more
europepmc   +1 more source

The expanding role of the receptor tyrosine kinase MET as a therapeutic target in non-small cell lung cancer. [PDF]

Cell Rep Med
Sattler M, Salgia R.
europepmc   +1 more source

Role of single‐nucleotide polymorphism microarray in the classification of BAP1‐inactivated melanocytic tumours

Histopathology, Volume 87, Issue 1, Page 110-129, July 2025.
Here we report the features of 24 BAP1‐inactivated melanocytic tumours including 19 BAP1‐inactivated melanocytomas (BIMs) and five BAP1‐inactivated melanomas. BIMs have a favourable prognosis, even those with multiple copy number aberrations (CNAs).
Joseph S. Durgin, Nicholas A. Zoumberos, Taylor Novice, Douglas R. Fullen, Alexandra C. Hristov, Lori Lowe, Rajiv M. Patel, Paul W. Harms, Aleodor A. Andea, Scott C. Bresler   +9 more
wiley   +1 more source

ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways. [PDF]

Ann Med
Lan Y, Liu D, Liang B, Song X, Xie L, Peng H, Guo H, Hong C, Weng X, Wei X, Liao X, Liang R, Huang D, Liu M.   +13 more
europepmc   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, Volume 19, Issue 6, Page 1633-1650, June 2025.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Development and application of a whole transcriptome sequencing assay for the detection of gene fusions in clinical cancer specimens. [PDF]

BMC Cancer
Zhao S, Du X, Zhang Y, Bai J, Meng L, Li X, Ma J, Sheng H, Fu X, Guan Y, Yi Y, Yang L, Xia X, Yi X, Tan X, Zhou C.   +15 more
europepmc   +1 more source

Role of cytomegalovirus in glioblastoma development: promoter or culprit? [PDF]

Virol J
Wu X, Zhang Z, Zhang L, Daniels DJ.
europepmc   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source