Results 41 to 50 of about 49,807 (253)

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The Effects of a Submaximal Endurance Swimming Training Period and Cadmium Poisoning during Pregnancy on the Hepatocyte Growth Factor Response in Neonatal Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Exposure to cadmium in early pregnancy has long-term effects on the growth and function of the liver. One of the pathways that controls proliferation of the fetal liver involves hepatocyte growth factor (HGF).
Hossein Ali Asgharzade Oliaei, Shadmehr Mirdar Harijani, Narges Mousavi   +2 more
doaj  

Pathogenesis of endocrine thyroid cancer [PDF]

, 2015
This review aims to discuss the different genetic alterations that may come about and thus give rise to thyroid cancer. The importance of understanding the pathogenesis of this disease is in the use of these genetic alterations as prognostic markers and ...
Mallia, Nicola, Vassallo, Josanne
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Role of Sam68 in post-transcriptional gene regulation [PDF]

, 2013
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing ...
Anderson, Andreotti, Arning, Auboeuf, Babic, Babic, Baehrecke, Barlat, Batsche, Bedford, Berson, Biamonti, Biamonti, Bianchi, Bielli, Burd, Busa, Busa, Chawla, Chen, Chen, Chen, Chen, Cheng, Cote, Cruz-Alvarez, Denegri, Derry, Di Fruscio, Di Fruscio, Dreyfuss, Ebersole, Finnen, Flora Sánchez-Jiménez, Fumagalli, Fusaki, Galarneau, Grossman, Guitard, Hartmann, Hawkins, Henao-Mejia, Hong, Huot, Huot, Iijima, Ishidate, Itoh, Jabado, Jauliac, Jones, Kim, Klein, Kunkel, Lang, Lawe, Li, Liao, Lin, Liu, Locatelli, Locatelli, Lukong, Lukong, Lukong, Lukong, Lynch, Maa, Martin-Romero, Matter, Messina, Meyer, Mezquita, Modem, Morishita, Najib, Najib, Naor, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Pedrotti, Pedrotti, Piotrowska, Porkka, Rajan, Rajan, Ramakrishnan, Reddy, Resnick, Richard, Richard, Richard, Rosenberger, Ru, Sanchez-Jimenez, Sanchez-Jimenez, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sellier, Sette, Simarro, Song, Soros, Stoss, Subramanyam, Suhasini, Tassone, Taylor, Taylor, Taylor, Tisserant, Tremblay, Trub, Ulke-Lemee, Valacca, Venables, Venigalla, Vernet, Víctor Sánchez-Margalet, Wang, Wang, Yang, Zhang, Zorn   +130 more
core   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Kinetics and Thermodynamics of Membrane Protein Folding [PDF]

Biomolecules 2014, 4(1), 354-373, 2014
Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute
arxiv   +1 more source

A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]

, 2012
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Reitter, Anke, Yuan, Juping   +4 more
core   +2 more sources

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source