Results 171 to 180 of about 79,488 (241)

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

GSK-J4 Suppresses Tumorigenesis by Targeting the PERK-c-Myc Pathway Through Endoplasmic Reticulum Stress Activation in Tuberous Sclerosis Complex. [PDF]

Int J Mol Sci
Lei X, Lang T, Li P, Wu C.
europepmc   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

A Conserved Enhancer Locus in Extrachromosomal DNA and Homogeneously Staining Regions Activates MYC Transcription in Group 3 Medulloblastoma. [PDF]

Cancer Res
Friske JD, Cuisin F, Guernalec P, Malone HA, Nance S, Bennett D, Burden SJ, Chang TC, Shi H, Williams JS, Valentine V, Passaia BDS, Ju B, Adetunji MO, Geeleher P, Abraham BJ, Wu G, Li C, Roussel MF.   +18 more
europepmc   +1 more source

Transcriptomics Analysis Reveals Dual Axes of Metabolic and Immune Dysregulation in the Progression of NAFLD to HCC

Natural Sciences, Volume 6, Issue 3, July 2026.
The mechanisms driving the progression of NAFLD through NASH, cirrhosis and HCC are unclear. In this study, we have comprehensively analyzed multi‐cohort transcriptomics data of the whole NAFLD spectrum to unlock the paradigm changes in gene expression and its regulation.
Anusha Patodia, Harikeshav Karthik, Sulagna Basu, Varshini Venkatesan, Rakesh Pandey, Gowri Manohari Balachander   +5 more
wiley   +1 more source

Identification of Critical miRNAs miR-4652 and miR-1304 as Novel Diagnostic Markers for Oral Squamous Cell Carcinoma. [PDF]

Cancer Rep (Hoboken)
Farahani SB, Keramati E, Etesami M, Jamshidian F.   +3 more
europepmc   +1 more source

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, Volume 86, Issue 10, Page 1103-1114, July 2026.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source

Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS. [PDF]

Nat Commun
Wang MM, Truica MI, Gattis BS, Oktawiec J, Sagar V, Basu AA, Bertin PA, Zhang X, Abdulkadir SA, Gianneschi NC.   +9 more
europepmc   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Dynamic, anthracycline-induced chromatin alterations enable ALDH1 expression as a mechanism of inducible leukemia resistance development. [PDF]

Blood Res
Vlahopoulos SA.
europepmc   +1 more source