Results 191 to 200 of about 79,488 (241)

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

Isolated signals in BCL2, MYC, BCL6, and DDIT3 FISH: implications for genetic alterations and protein dysregulation. [PDF]

Pathol Oncol Res
Wei Z, Chen Q, Feng Z, Tang F.
europepmc   +1 more source

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, Volume 158, Issue 12, Page 3268-3278, 15 June 2026.
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing Sarcoma. [PDF]

PLoS One
Kubota Y, Kawano M, Itonaga I, Kaku N, Tanaka K.   +4 more
europepmc   +1 more source

C-MYC as a key effector of WNT, PI3K/AKT, MAPK, and TGF-β signaling pathways in regulation of epithelial-mesenchymal transition during tumor metastasis. [PDF]

Cancer Cell Int
Moghbeli M.
europepmc   +1 more source

SHP2 promotes osteosarcoma via regulating STAT3/TET3/HOXB2 signaling. [PDF]

Sci Rep
Yang H, Ji J.
europepmc   +1 more source

Advancements and innovations in the molecular mechanisms and treatment of colorectal cancer. [PDF]

Discov Oncol
Wang X, Yang J.
europepmc   +1 more source

ARNT2 repression disrupts neuronal identity and promotes glioblastoma growth. [PDF]

Cell Commun Signal
Hao YH, Borenstein-Auerbach N, Grichuk A, Li L, Lafita-Navarro MC, Fang S, Nogueira PA, Kim J, Xu L, Shay JW, Conacci-Sorrell M.   +10 more
europepmc   +1 more source

OGT-Mediated O-GlcNAcylation Stabilizes c-Myc Activity and Promotes Chemoresistance in Triple-Negative Breast Cancer. [PDF]

Breast J
Li J, Zhang J.
europepmc   +1 more source