Results 1 to 10 of about 20,082,992 (152)

A biologia molecular no prognóstico do carcinoma da tireóide

Revista do Colégio Brasileiro de Cirurgiões, 2003
This overview examines some selected genetic mechanisms of cancer development. Strong evidence has been accumulated suggesting that alteration in either the struture or activity of proto-oncogene contributes to the development and for the maintenance of ...
Aluizio Soares de Souza Rodrigues
doaj   +2 more sources

An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene.

Gene Expression, 2005
Neural crest cells arise from the epithelium of the dorsal neural tube and migrate to various districts giving origin, among others, to sympathetic, parasympathetic, and enteric ganglia.
Isabella Ceccherini, Tiziana Bachetti, Silvia Borghini   +2 more
exaly   +2 more sources

Novel intronic polymorphisms in the RET proto-oncogene and their association with Hirschsprung disease†‡

Human Mutation, 2003
Andreas Ziegler, Hans K Schackert, Guido Fitze   +2 more
exaly   +2 more sources

Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion

BMC Cancer, 2019
Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-ros UR2 sarcoma virus oncogene ...
Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada, Yasushi Yoshimura   +5 more
doaj   +1 more source

A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro.

Science, 1988
The nuclear protein encoded by the proto-oncogene c-myb has been hypothesized to play an important role in the process of hematopoiesis, but direct proof of this function has been lacking. To address this issue, normal human bone marrow mononuclear cells
A. Gewirtz, Bruno Calabretta
semanticscholar   +1 more source

NRASQ61R Mutation-specific Immunohistochemistry Also Identifies the HRASQ61R Mutation in Medullary Thyroid Cancer and May Have a Role in Triaging Genetic Testing for MEN2

American Journal of Surgical Pathology, 2017
A quarter of patients with medullary thyroid carcinoma (MTC) have germline mutations in the RET proto-oncogene indicating MEN2. Therefore genetic testing is recommended for all patients presenting with MTC.
J. Reagh, Martyn Bullock, J. Andrici, J. Turchini, L. Sioson, A. Clarkson, N. Watson, Amy Sheen, Grace Lim, L. Delbridge, S. Sidhu, M. Sywak, Ahmad M Aniss, P. Shepherd, D. Ng, P. Oei, M. Field, D. Learoyd, B. Robinson, R. Clifton-Bligh, A. Gill   +20 more
semanticscholar   +1 more source

Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

Journal of Neuroscience, 1997
Glial cell line-derived neurotrophic factor (GDNF), the most potent trophic factor yet described for both dopaminergic neurons of the substantia nigra and spinal motorneurons, has recently been shown to signal through a multireceptor complex composed of ...
Miles Trupp, N. Belluardo, H. Funakoshi, C. Ibáñez   +3 more
semanticscholar   +1 more source

Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma

Clinical Cancer Research, 2015
Purpose: The RET proto-oncogene has been implicated in breast cancer, and the studies herein describe the preclinical and safety assessment of an anti-RET antibody–drug conjugate (ADC) being developed for the treatment of breast cancer.
Minh Nguyen, Shuichi Miyakawa, J. Kato, T. Mori, Toshimitsu Arai, M. Armanini, K. Gelmon, R. Yerushalmi, S. Leung, D. Gao, G. Landes, M. Haak‐Frendscho, K. Elias, A. Simmons   +13 more
semanticscholar   +1 more source

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene

Journal of experimental & clinical cancer research : CR, 2018
Improvement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits such as cancer recurrence and drug resistance.
Duarte Mendes Oliveira, K. Grillone, C. Mignogna, V. De Falco, C. Laudanna, F. Biamonte, Rosa Locane, Francesco Corcione, M. Fabozzi, R. Sacco, G. Viglietto, D. Malanga, A. Rizzuto   +12 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source