MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity [PDF]
We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system.
Anderson, David J. +2 more
core
The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo. [PDF]
Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET kinase
Flynn, Sean M +7 more
core
Study of GDNF-Family Receptor Alpha 2 And Inhibitory Activity of GDNF-Family Receptor Alpha 2b (GFRα2b) Isoform [PDF]
The glial cell-line derived neurotrophic factor (GDNF) and neurturin (NTN) belong to a structurally related family of neurotrophic factors. NTN exerts its effect through a multi-component receptor system consisting of the GDNF family receptor alpha 2 ...
Too, Heng-Phon, Yoong, Li Foong
core
The c-ros tvrosine kinase receptor I controls regionalization and differehiation of epithelial cells in the epididymis [PDF]
The c-ros gene was originally identified in mutant form as an oncogene. The proto-oncogene encodes a tyrosine kinase receptor that is expressed in a small number of epithelial cell types, including those of the epididymis.
Birchmeie, Carmen +4 more
core
Sporadic endocrine tumours and their relationship to the hereditary endocrine neoplasia syndromes [PDF]
Koper, J.W. (Jan) +1 more
core +1 more source
Gene structure of the human receptor tyrosine kinase Ron and mutation analysis in lung cancer samples. [PDF]
ANGELONI, DEBORA +6 more
core +1 more source
A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer [PDF]
Baranski, Thomas +8 more
core +1 more source
Landscape of Genomic Mechanisms of Resistance to Selective RET Inhibitors in RET-Altered Solid Tumors: Analysis of the RETgistry Global Consortium. [PDF]
Waliany S +37 more
europepmc +1 more source
Molecular Pathology of Advanced NSCLC: Biomarkers and Therapeutic Decisions. [PDF]
Winter M +4 more
europepmc +1 more source

