Results 61 to 70 of about 29,629 (128)
Molecular and cellular pathogenesis of melanoma initiation and progression [PDF]
, 2013 Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core +1 more source
KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
Advanced Science, Volume 13, Issue 6, 30 January 2026.Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao +9 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells [PDF]
, 2015 AIMS/HYPOTHESIS: Rho GTPases (Ras-related C3 botulinum toxin substrate 1 [Rac1] and cell division cycle 42 [Cdc42]) have been shown to regulate glucose-stimulated insulin secretion (GSIS) via cytoskeletal remodelling, trafficking and fusion of insulin ...
Arora, Daleep Kumar +7 more
core +2 more sources
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis [PDF]
, 2015 Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis.
Alamsahebpour, Amir +9 more
core +1 more source
The role of p21-activated kinases in hepatocellular carcinoma metastasis [PDF]
, 2014 The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis.
Ching, YP, Tse, EYT
core +1 more source
Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems [PDF]
, 2000 18 pages, 2 figures, 1 table.-- Review.This review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by ...
Medina, Diego L., Santisteban, Pilar
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Rho GTPases and signaling networks [PDF]
, 1997 The Rho GTPases form a subgroup of the Ras superfamily of 20- to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man.
D'Souza-Schorey, C., Van Aelst, L.
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Physical mapping and cloning of the t(3;8)(p21;q12)translocation breakpoints in pleomorphic adenomas [PDF]
, 1997 The pleomorphic adenoma is a benign epithelial tumor originating from the major and minor salivary glands. It is the most common type of salivary gland tumor, accounting for almost half of all neoplasms in these organs.
Röijer, Eva 1967-
core
, 2006 Cyclin-dependent kinase (CDK)4 is a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. It is also crucial for many oncogenic transformation processes.
Laurence Bockstaele +4 more
core +2 more sources