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Computing with Synthetic Protocells
Acta Biotheoretica, 2015In this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates. The architecture of a computing machine relies on these generic and composable building blocks, computation units, that can be used in multiple instances to perform complex boolean functions.
Courbet, Alexis +2 more
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2017
The monograph discusses models of synthetic protocells, which are cell-like structures obtained from non-living matter endowed with some rudimentary kind of metabolism and genetics, but much simpler than biological cells. They should grow and proliferate, generating offsprings that resemble in some way the parent protocells with some variation, so that
Roberto Serra, Marco Villani
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The monograph discusses models of synthetic protocells, which are cell-like structures obtained from non-living matter endowed with some rudimentary kind of metabolism and genetics, but much simpler than biological cells. They should grow and proliferate, generating offsprings that resemble in some way the parent protocells with some variation, so that
Roberto Serra, Marco Villani
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2008
The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory.
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The first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. Protocells offers a comprehensive resource on current attempts to create simple forms of life from scratch in the laboratory.
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Computer Simulation of Protocells
2003When attempting to analyze, simulate and comprehend a vastly complex network such as a present-day living cell, one face enormous computing burden. Our group has in last decade worked on analyzing with similar methodologies the chemical behavior of much simpler systems, namely protocells.
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The chemical logic of a minimum protocell
Origins of life and evolution of the biosphere, 1988Traditional schemes for the origin of cellular life on earth generally suppose that the chance assembly of polymer synthesis systems was the initial event, followed by incorporation into a membrane-enclosed volume to form the earliest cells. Here we discuss an alternative system consisting of replicating membrane vesicles, which we define as minimum ...
H J, Morowitz, B, Heinz, D W, Deamer
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1997
Cellularization has the following main aspects that we have to explain: • The need for active (self-generated) compartmentation when metabolism is liberated from the surface. • The origin of membranogenic molecules and membranes. • The origin and mechanism of spontaneous protocell fission. • The transportation problem.
John Maynard Smith, Eors Szathmary
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Cellularization has the following main aspects that we have to explain: • The need for active (self-generated) compartmentation when metabolism is liberated from the surface. • The origin of membranogenic molecules and membranes. • The origin and mechanism of spontaneous protocell fission. • The transportation problem.
John Maynard Smith, Eors Szathmary
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Toward Understanding Protocell Mechanosensation
Origins of Life and Evolution of Biospheres, 2010Mechanosensitive (MS) channels can prevent bacterial bursting during hypo-osmotic shocks by responding to increases in lateral tension at the membrane level through an integrated and coordinated opening mechanism. Mechanical regulation in protocells could have been one of the first mechanisms to evolve in order to preserve their integrity against ...
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Protocell Research and Its Implications
Perspectives in Biology and Medicine, 2010If and when protocells exist, they will exhibit three requisites for life: regeneration, replication, and evolution. Based on a recent collection of articles, this essay examines two major questions: (1) should research on development of protocells continue, and (2) what are the implications of this research for our understanding of "life."On the first
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2009
Experts explore the potential benefits, risks, and moral aspects of protocell technology, which creates simple forms of life from nonliving material. Teams of scientists around the world are racing to create protocells—microscopic, self-organizing entities that spontaneously assemble from simple organic and inorganic materials.
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Experts explore the potential benefits, risks, and moral aspects of protocell technology, which creates simple forms of life from nonliving material. Teams of scientists around the world are racing to create protocells—microscopic, self-organizing entities that spontaneously assemble from simple organic and inorganic materials.
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Physics Underlying the Formation of Protocells
Journal of Biological Physics, 1995The emergence of the first cellular organization on the primitive earth could be associated with pronounced heterotrophic activity embodied in heat engines actualized in local material aggregates. Heterotrophic activity intrinsically rests upon the capacity of local detection upholding the conservation of energy on the global scale.
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