Results 191 to 200 of about 3,502,365 (268)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Efficacy and toxicity of neoadjuvant chemotherapy versus chemo-immunotherapy in triple-negative breast cancer patients with and without germline BRCA mutations. [PDF]

Breast Cancer Res Treat
Etan T, Cohen L, Bar Y, Leshem Y, Lerner S, Stepansky I, Shiran I, Sonnenblick A, Shachar SS.   +8 more
europepmc   +1 more source

VibroIntegração BioMolecular: a structured multimodal protocol for autonomic regulation in community healthcare. [PDF]

Front Public Health
Braga ES, de Souza Teixeira F.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Activity-Based Functional Exercise for Disability in Systemic Sclerosis: Protocol for a Feasibility Randomised Controlled Trial. [PDF]

Musculoskeletal Care
da Silva Santos G, Soares AN, Porto Soares GM, Medeiros de Lima TA, Fernandes J, Branco Pinto Duarte AL, da Silva Tenório A, Dantas AT.   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Voice as a predictive signal: protocol for a scoping review of AI in early childhood development. [PDF]

BMJ Open
Amir-Behghadami M, Heidarabadi S.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Protocol for multiplexed transcription factor activity detection using optimized barcoded reporters and an automated computational pipeline. [PDF]

STAR Protoc
Trauernicht M, Franceschini-Santos VH, Yücel H, Steensel BV.   +3 more
europepmc   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO-DS21 Mouse Model: Investigating Down Syndrome Comorbidities. [PDF]

Curr Protoc
Selloum M, Silva-Buttkus PD, Riet F, Dragano NRV, Garrett L, Jacobs H, Hölter SM, Torquet N, Rathkolb B, Lindner L, Gailus-Durner V, Pavlovic G, Chan L, Beckers J, Demoulière BP, Fuchs H, Ey E, Sorg T, Angelis MH, Herault Y, GO‐DS21 Consortium.   +20 more
europepmc   +1 more source