Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Letter to the editor regarding to "effect of Tai Chi combined with visual-action-sensory rehabilitation therapies on cognitive function in acute ischemic stroke: a study protocol for a randomized controlled trial". [PDF]
Fu X, Huang S.
europepmc +1 more source
Towards Verification of the Pastry Protocol Using TLA +
Tianxiang Lu +2 more
openalex +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Prospective Registration of Clinical Trial Protocols: When Is a Health-Related Intervention Study Not a 'Clinical Trial'? [PDF]
Bressington D +3 more
europepmc +1 more source
Towards the co‐ordination of terrestrial ecosystem protocols across European research infrastructures [PDF]
L. G. Firbank +13 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Image Cytometry Protocols [PDF]
van Noorden, Cornelis J. F. +1 more
openaire +2 more sources

