Results 241 to 250 of about 3,341,855 (333)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Involving family caregivers in co-design research: a systematic review protocol for developing evidence-based engagement strategies. [PDF]

BMJ Open
Alfaro-Diaz C, Rothausen CS, Bonde Hansen EV, Samuelsson M.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stimulating training and access to HIV research experiences (STAR program): a protocol for a crowdsourced, project-based, implementation science training program using mixed-methods design [PDF]

Juliet Iwelunmor, Idia B. Thurston, Collins O. Airhihenbuwa, Weiming Tang, Ucheoma Nwaozuru, Onyekachukwu Anikamadu, David Oladele, Bryce Puesta Takenaka, Khadijah Ameen, Olufunto A. Olusanya, Temitope Ojo, Joseph D. Tucker   +11 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Informationally complete distributed metrology without a shared reference frame. [PDF]

Nat Commun
Xu HQ, Li GC, Hong XS, Chen L, Zhang SQ, Liu Y, Chen G, Li CF, Guo GC.   +8 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Protocol to analyze steps of ribosome biogenesis in nuclear and cytosolic fractions of yeast cells. [PDF]

STAR Protoc
Zadali R, Topf U.
europepmc   +1 more source

Calibration protocols in-situ and citizen science

D5.4 In-field calibration protocols for in situ observations and citizen science data collection.
openaire   +1 more source

The ODE (Overview, Data, and Execution) protocol for a standardized use of machine learning in environmental, social and related interdisciplinary sciences

Samuel Seuru, Volker Grimm, Michael Barton, Liliana Perez, Navid Mahdizadeh Gharakhanlou, Raja Sengupta, Alejandro Miguel Dagnino   +6 more
openalex   +1 more source