Results 111 to 120 of about 5,838,160 (343)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Speeding Up VM Image Distribution for Cloud Data Centers

open access: yesAdvances in Electrical and Computer Engineering, 2016
An efficient scheme of virtual machine image dissemination, which takes up a major portion of VM provisioning time, is key to ensuring that the service can be provisioned and delivered to clients in a timely manner.
LEE, C., LEE, H., KIM, E.
doaj   +1 more source

Synthesizing Secure Protocols [PDF]

open access: yes, 2007
We propose a general transformation that maps a cryptographic protocol that is secure in an extremely weak sense (essentially in a model where no adversary is present) into a protocol that is secure against a fully active adversary which interacts with an unbounded number of protocol sessions, and has absolute control over the network.
Cortier, Veronique   +2 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Protocolo para captação dos potenciais evocados auditivos de longa latência Protocol to collect late latency auditory evoked potentials

open access: yesBrazilian Journal of Otorhinolaryngology, 2009
Os potenciais evocados auditivos de longa latência (PEALLs) se referem a uma série de mudanças elétricas, ocorridas no sistema nervoso central, resultante da estimulação da via sensorial auditiva.
Luzia Maria Pozzobom Ventura   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Automatic analysis of distance bounding protocols [PDF]

open access: yes, 2009
Distance bounding protocols are used by nodes in wireless networks to calculate upper bounds on their distances to other nodes. However, dishonest nodes in the network can turn the calculations both illegitimate and inaccurate when they participate in ...
Bruhadeshwar, Bezawada   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

eTDP: Enhanced Topology Discovery Protocol for Software-Defined Networks

open access: yesIEEE Access, 2019
Discovering network elements in a dynamic and optimized manner and being able to contend with ever-growing traffic is a key requirement for current networking environments.
Leonardo Ochoa-Aday   +2 more
doaj   +1 more source

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