In vitro evaluation of dioscin and protodioscin against ER-positive and triple-negative breast cancer [PDF]
PLoS ONE, 2023 Women’s breast cancer is one of the most significant healthcare issues for the human race that demands a proactive strategy for a cure. In this study, the cytotoxic activity (MTT assay) of two natural steroidal compounds, protodioscin and dioscin ...
Najat Bouchmaa +7 more
doaj +4 more sources
Chemical Comparison and Identification of Xanthine Oxidase Inhibitors of Dioscoreae Hypoglaucae Rhizoma and Dioscoreae Spongiosae Rhizoma by Chemometric Analysis and Spectrum–Effect Relationship [PDF]
Molecules, 2023 Dioscoreae hypoglaucae Rhizoma (DH) and Dioscoreae spongiosae Rhizoma (DS) are two similar Chinese herbal medicines derived from the Dioscorea family. DH and DS have been used as medicines in China and other Asian countries for a long time, but study on ...
Guo Rui +6 more
doaj +2 more sources
ANN modeling and RSM optimization of ultrasound-assisted extraction of protodioscin-rich extracts from Tribulus terrestris L. [PDF]
Ultrasonics SonochemistryTribulus terrestris L. is a herb renowned for its abundance of saponins, flavonoids, and alkaloids, which are utilized in treating various health conditions.
Stefan Kuvendziev +3 more
doaj +2 more sources
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin [PDF]
Chinese MedicineBackground Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in
Qian Zeng +14 more
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Content of the Saponin Protodioscin in Brachiaria spp. From the Eastern Plains of Colombia
Toxins, 2017 Protodioscin is used as a marker of saponin content that could cause hepatotoxicity in ruminants. In Brachiaria spp. from two regions of the Colombian Eastern Plains (east mountain range of the Andean—“piedemonte” and Ariari River Valley) were determined
Maria C Lozano +2 more
exaly +3 more sources
Protective effects of methyl protodioscin against lipid disorders and liver injury in hyperlipidemic gerbils [PDF]
Heliyon, 2023 Methyl protodioscin (MPD) is the main component of total diosgenin, which was reported to reduce cholesterol and triglyceride levels potentially. This study aimed to investigate the beneficial effects of MPD against lipid disorder in hyperlipidemic ...
Xiaojia Chen +9 more
doaj +2 more sources
A tri-target in silico analysis of Testolift: a nutraceutical formulation targeting aromatase, myostatin, and prolyl hydroxylase-2 in testosterone regulation and muscle performance [PDF]
Scientific ReportsDeclining testosterone levels and associated impairments in muscle function, endurance, and metabolic health represent a growing global concern, while limitations associated with long-term testosterone replacement therapy have intensified interest in ...
Augustine Amalraj +5 more
doaj +2 more sources
Methyl Protodioscin Promotes Ferroptosis of Prostate Cancer Cells by Facilitating Dissociation of RB1CC1 from the Detergent-Resistant Membranes and Its Nuclear Translocation [PDF]
BiomoleculesMethyl protodioscin (MPD), a furostanol saponin found in the rhizomes of Dioscorea plants, has been shown to effectively inhibit proliferation of prostate cancer cells in vitro and in vivo. However, the mechanism underlying this inhibitory action remains
Ruonan Wang +7 more
doaj +2 more sources
Protodioscin mitigates cyclophosphamide-induced renal toxicity in HEK-293 cells by regulating endoplasmic reticulum stress, antioxidant defense, and apoptotic pathways. [PDF]
PLoS ONECyclophosphamide (CTX) is a widely used chemotherapeutic agent with well-established efficacy; however, its clinical use is limited by dose-dependent adverse effects, particularly nephrotoxicity.
Ahmad Reza Ahmadi +4 more
doaj +2 more sources
Protodioscin enhances Methotrexate-induced senescence and senolytic activity in HepG2 liver cancer spheroids by modulating cell cycle regulators and the TGF-β/p-Smad2-4 signaling pathway [PDF]
Scientific ReportsProtodioscin (PD) is a natural saponin with anti-inflammatory, anticancer, and metabolic regulatory properties. Senolytic agents, which selectively eliminate senescent cells, are gaining attention for enhancing cancer therapy.
Alborz Jafaei Souq +6 more
doaj +2 more sources