Results 31 to 40 of about 1,023 (167)

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum. [PDF]

Plant Biotechnol J
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Lim J, Kim K, Heo J, Seo SM, Choung S, Kim H, Choi Y, Park K, Yun H, Kim D, Lee ES, Lee J, Warsadiharja SM, Lee SB, Han S, Park SJ, Kim SG.   +16 more
europepmc   +2 more sources

Protodioscin Restores Ovarian Function and Suppresses p53-Bax/Bcl-2-Mediated Apoptosis in a Doxorubicin-Induced Model of Ovarian Toxicity. [PDF]

Adv Pharm Bull
Purpose: This study evaluated the protective effects of protodioscin against doxorubicin (DOX)-induced ovarian injury by examining its potential to modulate hormonal alterations and apoptosis-related pathways in a rat model.
Abou-El-Naga AM, Abd-Elhady AM, Abdraboh ME, Tag YM, Akl MM.   +4 more
europepmc   +2 more sources

The Production of Marandu Grass (Urochloa brizantha) Extracts as a Natural Modifier of Rumen Fermentation Kinetics Using an In Vitro Technique

Fermentation
The ethanolic (EE) and hydroalcoholic (HE) extracts of Urochloa brizantha concentrations were developed with the aim of evaluating their effect on rumen fermentation using an in vitro gas production technique.
Rafaela Scalise Xavier de Freitas, Janaina Silveira da Silva, Althieres José Furtado, Flavio Perna Junior, Alessandra Lopes de Oliveira, Ives Cláudio da Silva Bueno   +5 more
doaj   +2 more sources

Steroidal saponin concentrations in Brachiaria decumbens and B. brizantha at different developmental stages Concentrações de saponina esteroidal em diferentes fases do desenvolvimento de Brachiaria decumbens e B. brizantha

Ciência Rural, 2009
Brachiaria species contain steroidal saponins and are involved in outbreaks of hepatogenous photosensitization. This research presents the levels of a steroidal saponin, protodioscin, in the seeds and aerial parts of B. brizantha and B.
Karine Bonucielli Brum, Mitsue Haraguchi, Mirella Biasoli Garutti, Fernanda Nogarol Nóbrega, Beneval Rosa, Maria Clorinda Soares Fioravanti   +5 more
doaj   +1 more source

Protodioscin protects porcine oocytes against H2O2-induced oxidative stress during in vitro maturation [PDF]

Animal Bioscience, 2023
Objective The present study investigated whether protodioscin (PD), a steroidal saponin mainly found in rhizome of Dioscorea species, alleviates oxidative stress-induced damage of porcine oocytes during in vitro maturation.
So-Hee Kim, Seung-Eun Lee, Jae-Wook Yoon, Hyo-Jin Park, Seung-Hwan Oh, Do-Geon Lee, Da-Bin Pyeon, Eun-Young Kim, Se-Pill Park   +8 more
doaj   +1 more source

Chemical structures of protodioscin (A) and dioscin (B).

, 2023
Chemical structures of protodioscin (A) and dioscin (B).
Francesco Cacciola (762130), Rachid El Fatimy (13558834), Mohamed Nhiri (13558831), Abdelmajid Zyad (773362), Najat Bouchmaa (13558816), Sana Ajouaoi (14593126), Youssef Bouargalne (14593123), Reda Ben Mrid (13558813)   +7 more
core   +2 more sources

Assessment of suitable region of <i>Asparagus cochinchinensis</i> (Lour.) Merr. under different climatic conditions in China by the MaxEnt model and HPLC analysis. [PDF]

Ecol Evol
Species distribution model is used to predict the distribution of suitable habitats of Asparagus cochinchinensis (Lour.) Merr. in China. Precipitation and temperature are the key factors affecting the accumulation of active components in A. cochinchinensis. Saponins and total polysaccharides contents show different response patterns to climatic factors.
Zhang T, Lv X, Zhao Q, Zhang C, Yin H, Deng S, Yan G, Wang G, Cao X, Ou H, Shen G.   +10 more
europepmc   +2 more sources

Total Synthesis of Methyl Protodioscin: A Potent Agent with Antitumor Activity. [PDF]

ChemInform, 2003
Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3 beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.
Mao S, Cheng, Qian L, Wang, Quan, Tian, Hong Y, Song, Yong X, Liu, Qiang, Li, Xin, Xu, Hong D, Miao, Xin S, Yao, Zhen, Yang   +9 more
openaire   +2 more sources

The role of mitochondrial dynamics in disease

MedComm, Volume 4, Issue 6, December 2023., 2023
Mitophagy is a form of selective autophagy in which damaged mitochondrial fragment is devoured and degraded, triggered by cues that mark mitochondrial damage, such as imbalance in mitochondrial fission–fusion dynamics. Abstract Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction ...
Yujuan Wang, Xinyan Dai, Hui Li, Huiling Jiang, Junfu Zhou, Shiying Zhang, Jiacheng Guo, Lidu Shen, Huantao Yang, Jie Lin, Hengxiu Yan   +10 more
wiley   +1 more source

Suspension Cell Culture of Dioscorea deltoidea—A Renewable Source of Biomass and Furostanol Glycosides for Food and Pharmaceutical Industry

Agronomy, 2021
Dioscorea deltoidea is a medicinal plant valued for its high content of steroidal glycosides (SG)—bioactive compounds with cardioprotective and immunomodulation actions, also used to treat reproductive system disorders.
Maria V. Titova, Elena V. Popova, Svetlana V. Konstantinova, Dmitry V. Kochkin, Igor M. Ivanov, Andrey G. Klyushin, Elena G. Titova, Elena A. Nebera, Ekaterina R. Vasilevskaya, Galina S. Tolmacheva, Elena A. Kotenkova, Alexandr M. Nosov, Kee-Yoeup Paek   +12 more
doaj   +1 more source