Results 91 to 100 of about 7,610 (197)

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, Volume 183, Issue 9, Page 1939-1957, May 2026.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Chromaffin cells and platelets both utilize exocytosis to release biogenic amines stored within large dense‐core vesicles—specifically chromaffin granules (epinephrine) and δ‐granules (serotonin). While the chromaffin cell is the foundational model for studying the secretory pathway, platelets offer a highly accessible human cell source for clinical ...
Ricardo Borges
wiley   +1 more source

The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition

New Phytologist, Volume 250, Issue 3, Page 1619-1633, May 2026.
Summary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Shunsuke Watanabe, Meijie Li, Alice Rossille, Chérhazad Boustani, Kevin Robe, Yuri Kanno, Mitsunori Seo, Christian Dubos   +7 more
wiley   +1 more source

Monitoring transient elastic energy storage within the rotary motors of single FoF1-ATP synthase by DCO-ALEX FRET

, 2012
The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the three ATP binding
Boersch, Michael, Dueser, Monika G., Ernst, Stefan, Zarrabi, Nawid   +3 more
core   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Crystallization, Structure and Dynamics of the Proton-Translocating P-Type ATPase

Journal of Experimental Biology, 2000
ABSTRACT Large single three-dimensional crystals of the dodecylmaltoside complex of the Neurospora crassa plasma membrane H+-ATPase (H+P-ATPase) can be grown in polyethylene-glycol-containing solutions optimized for moderate supersaturation of both the protein surfaces and detergent micellar region.
openaire   +3 more sources

Fourth Symposium on Chemical Evolution and the Origin and Evolution of Life [PDF]

This symposium was held at the NASA Ames Research Center, Moffett Field, California, July 24-27, 1990. The NASA exobiology investigators reported their recent research findings. Scientific papers were presented in the following areas: cosmic evolution of
Andersen, Dale T., Bzik, Sara E., Rummel, John D., Wharton, Robert A., Jr.   +3 more
core   +1 more source

ProAD - A database of rotary ion-translocating ATPases in prokaryotic genomes. [PDF]

Front Mol Biosci
Litvin AV, Lapashina AS, Ermidis AP, Gelfand MS, Feniouk BA.   +4 more
europepmc   +1 more source

NMR assignments of the human homodimeric mitochondrial ATP synthase inhibitor IF1. [PDF]

Biomol NMR Assign
Jerolamon J, Alder NN, Alexandrescu AT.
europepmc   +1 more source

Functional and structural characterization of F₁-ATPase with common ancestral core domains in stator ring. [PDF]

Protein Sci
Suzuki AK, Furukawa R, Sobti M, Brown SHJ, Stewart AG, Akanuma S, Ueno H, Noji H.   +7 more
europepmc   +1 more source