Results 71 to 80 of about 402,722 (159)

Chronic Contractile Activity Remediates Lysosomal Dysfunction in a Muscle Cell Lysosomal Disease Model

Journal of Cellular Physiology, Volume 241, Issue 9, September 2026.
Bafilomycin A1‐induced lysosomal dysfunction can be mitigated by CCA in muscle myotubes. The curcumin analogue C1 similarly decreases lysosomal accumulation, modestly improves function and increases mitochondrial content, suggesting that both CCA and C1 may represent potential strategies for alleviating lysosomal dysfunction and supporting muscle cell ...
Debasmita Bhattacharya, Neushaw Moradi, David A. Hood   +2 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Three proton-pumping ATPases in yeast.

, 1986
Yeast cells contain three distinct proton-pumping ATPases associated with the mitochondrial, vacuolar or plasma membranes.
Boutry, Marc, Goffeau, André
core  

Investigation of three accessory subunits of complex I from Yarrowia lipolytica [PDF]

, 2010
The nicotinamide-adenine-dinucleotide (NADH):ubiquinone oxidoreductase (complex I) from the strictly aerobic yeast Y. lipolytica contains at least 26 “accessory” subunits however the significance of most of them remains unknown. The aim of this study was
Dobrynin, Krzysztof
core  

Structure and conformational dynamics of the Pseudomonas CbrA transceptor

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The CbrA protein is a central regulator of carbon metabolism, biofilm formation, and virulence in Pseudomonas species, but the molecular mechanisms by which CbrA links nutrient sensing to downstream signaling has remained unclear. CbrA is a rare “transceptor” that combines membrane transporter and histidine kinase domains into a single ...
Melanie A. Orlando, Tejas Shah, Matthew W. Faber, Samik Bose, Benjamin J. Orlando   +4 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

BcMFSR Is Required for Efficient Uptake of Exogenous dsRNA and Spray‐Induced Gene Silencing in Botrytis cinerea

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
Spray‐induced gene silencing (SIGS) uses exogenous dsRNA to silence pathogen genes and control grey mould disease. We identify BcMFSR, an MFS protein required for dsRNA uptake and SIGS efficacy in Botrytis cinerea. Loss of BcMFSR abolishes dsRNA internalization and disease suppression, revealing a novel role for MFS proteins.
Le Xu, Ze Yu, Ruonan Du, Huijie Ma, Xiaoxiao Hu, Ran Wei, Qiwang Hu, Cong Sheng, Wambui Doris Njoki, Pan Chen, Xuechao Shi, Cheng Tang, Huameng Zhang, Shaoxia Zhou, Haoming Zhong, Weishu Wang, Isashova Umida, Hongwei Zhao   +17 more
wiley   +1 more source

Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding

New Phytologist, Volume 251, Issue 6, Page 3142-3158, September 2026.
Jasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Fay Bennett, Erin Stroud, Pradeep Kachroo, Murray Grant   +3 more
wiley   +1 more source

Substrates, regulation, cellular functions, and disease associations of P4-ATPases [PDF]

P4-ATPases, a subfamily of the P-type ATPase superfamily, play a crucial role in translocating membrane lipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet. This process generates and regulates transbilayer lipid asymmetry.
Shin, Hye-Won, Takatsu, Hiroyuki
core   +1 more source

Essential mitochondrial activity in Physcomitrium patens relies on complementary cytochrome and alternative oxidase pathways

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Mitochondrial respiration catalyses the transfer of electrons from NADH to oxygen through the activity of five multiprotein complexes. In plants, mitochondria also possess additional alternative electron transport pathways, including the alternative oxidase (AOX) pathway, which transfers electrons from ubiquinol to O2, bypassing the cytochrome ...
Shun‐Ling Tan, Antoni M. Vera‐Vives, Heyu Wang, Xing Huang, Claudia Beraldo, Alessandro Alboresi, Tomas Morosinotto   +6 more
wiley   +1 more source