Results 61 to 70 of about 420,897 (152)

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase

, 2015
Eukaryotic vacuolar H+-ATPases (V-ATPases) are rotary enzymes that use energy from hydrolysis of ATP to ADP to pump protons across membranes and control the pH of many intracellular compartments.
Zhao, Jianhua, Samir Benlekbir, John L. Rubinstein, Benlekbir, Samir, Jianhua Zhao, Rubinstein, John L.   +5 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

I hereby declare that the work presented in this document is based on research carried out by me, and that no part has previously been submitted for a degree in this or any other university [PDF]

, 1995
Inhibitors of known transport processes, in conjunction with ion substitution were used in biochemical, physiological and microelectrode studies to investigate the mechanisms underlying ion and fluid secretion across the Malpighian tubules of Locusta ...
Marshall, Sarah Louise
core  

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Cellular Mechanisms of H+ and HCO3- transport in tight urinary epithelia

, 1992
The sections in this article are: 1 Transepithelial Proton and Bicarbonate Transport 1.1 Intercalated Cells 1.2 Proton Secretion 1.3 Bicarbonate Secretion 2 Molecules Involved in Acid-Base Transport 2.1 Proton-Translocating ATPases 2.2 Cl−−inline image ...
Qais Al‐Awqati, Al-Awqati, Qais, Beauwens, Renaud, Renaud Beauwens   +3 more
core   +1 more source

Coupling between catalytic sites and the proton channel in F1F0-type ATPases

, 1994
F1F0-type ATPases catalyse both ATP-driven proton translocation and proton-gradient-driven ATP synthesis. Recent cryoelectronmicroscopy and low-resolution X-ray studies provide a first glimpse at the structure of this complicated membrane-bound enzyme ...
Capaldi R. A., Turina P., Aggeler R., Wilkens S.   +3 more
core   +1 more source

Structure and mechanism of mitochondrial proton-translocating transhydrogenase [PDF]

, 2019
Proton-translocating transhydrogenase (also known as nicotinamide nucleotide transhydrogenase (NNT)) is found in the plasma membranes of bacteria and the inner mitochondrial membranes of eukaryotes.
Leonid A. Sazanov, Domen Kampjut, Kampjut, Domen ; https://orcid.org/, Sazanov, Leonid A ; https://orcid.org/   +3 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Rice Productivity in Saline–Alkaline Soils: Constraints, Microbiome‐Mediated Regulation and Management Strategies

Journal of Agronomy and Crop Science, Volume 212, Issue 6, November 2026.
ABSTRACT Saline–alkaline soils are widespread and represent a particularly restrictive environment for rice, especially in arid and semi‐arid regions. These soils commonly combine elevated salinity with high pH, sodium‐related soil constraints and bicarbonate/carbonate accumulation, resulting in severe physicochemical and nutritional limitations. Under
Xiang Zhang, Jun Li, Yue Jiang, Qingqing Ma, Xiaoyu Geng, Yang Liu, Yinglong Chen, Pinglei Gao, Huanhe Wei, Qigen Dai   +9 more
wiley   +1 more source