Results 51 to 60 of about 402,722 (159)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity. [PDF]

, 2015
The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole.
Adam P Levine, Michael R Duchen, Peter R. Rich, Anthony W. Segal, Adam P. Levine, de Villiers, S, Anthony W Segal, Simon de Villiers (725764), Peter R. Rich (725765), Michael R. Duchen (49273), Peter R Rich, Levine, AP, Duchen, MR, Simon de Villiers, Michael R. Duchen, Rich, PR, Adam P. Levine (473969), Anthony W. Segal (251124), Segal, AW   +18 more
core   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

The lower γ region supports forward rotation in the latter half of the 80° substep of F1‐ATPase

Protein Science, Volume 35, Issue 10, October 2026.
Abstract F1‐ATPase achieves unidirectional rotation of its γ shaft through coordinated conformational cycling of the α3β3 ring, yet how shaft–ring interactions contribute to the directionality of rotation remains unclear. Here we analyzed an axle‐less TF1, in which the lower γ region is truncated, by combining single‐molecule rotation assays with cryo ...
Tomo Uchiyama, Hiroshi Ueno, Meghna Sobti, Emily J. Furlong, Simon H. J. Brown, Alastair G. Stewart, Hiroyuki Noji   +6 more
wiley   +1 more source

H+-ATPsintetase de cloroplastos (CF0F1): interação enzima/substrato ; efeito de espécies reativas de oxigênio e de nitrogênio em lipossomas [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Morfim, Marcos Paulo
core  

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K‐ATPase Mutation

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Christian Staehr, Tue Duy Nguyen, Tina Myhre Pedersen, Mikkel Vendelbo, Hans Christian Beck, Mads Kjolby, Rajkumar Rajanathan, Elena V. Bouzinova, Niels Jessen, Per Bendix Jeppesen, Alexander V. Chibalin, Vladimir V. Matchkov   +11 more
wiley   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

, 2007
Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental ...
Agnes Michalczyk (13056828), Belinda Mary Hardman (13052154), J Camakaris (13278537), M Greenough (13280541), Julian Mercer (13076475), Leigh Ackland (13080843)   +5 more
core  

Structure and regulation of the vacuolar ATPases [PDF]

, 2008
The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps responsible for both acidification of intracellular compartments and, for certain cell types, proton transport across the plasma membrane.
Forgac, Michael, Cipriano, Daniel J., Hinton, Ayana, Qi, Jie, Wang, Yanru, Bond, Sarah, Jefferies, Kevin C.   +6 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source