Results 51 to 60 of about 420,897 (152)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Functional dissection of the proton pumping modules of mitochondrial complex I [PDF]

, 2011
Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex
Zwicker Klaus, Nina Morgner, Esther Nübel, Radermacher, Michael, Lucie Sokolova, Dröse, Stefan, Stefan Kerscher, Zickermann, Volker, Brandt, Ulrich, Barth, Hans-Dieter, Nübel, Esther, Mirco Steger, Bernhard Brutschy, Stefan Dröse, Volker Zickermann, Brutschy, Bernd, Morgner, Nina, Stephanie Krack, Klaus Zwicker, Heide Heinrich, Brutschy Bernhard, Krack, Stephanie, Radermacher Michael, Heide, Heinrich, Hans-Dieter Barth, Ulrich Brandt, Zwicker, Klaus, Sokolova, Lucie, Steger Mirco, Michael Radermacher, Sokolova Lucie, Barth Hans-Dieter, Kerscher Stefan, Morgner Nina, Zickermann Volker, Nübel Esther, Kerscher, Stefan, Krack Stephanie, Steger, Mirco, Heinrich Heide, Brandt Ulrich, Dröse Stefan   +41 more
core   +2 more sources

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly

, 2008
Vacuolar ATPases (V-ATPases) are ATP-dependent proton pumps that maintain the acidity of cellular compartments. They are composed of a membrane-integrated proton-translocating V(0) and an extrinsic cytoplasmic catalytic domain V(1), joined by several ...
Venzke, David, Böttcher, Bettina, Batisse, C., Fethiere, J., Diepholz, Meikel, Rössle, Manfred, Svergun, D. I., Prinz, Simone, Florchinger, B., Roessle, M., Venzke, D., Bottcher, B., Svergun, Dmitri, Flörchinger, Beate, Prinz, S., Diepholz, M., Batisse, Claire, Féthière, James   +17 more
core   +1 more source

Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [PDF]

, 2012
Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic alkalinisation, increased acid
Hernández López, Agustín, Serrano Bueno, Gloria, Serrano Delgado, Aurelio, Pérez Castiñeira, José Román   +3 more
core   +1 more source

Functional Analysis of the Plasma Membrane H(+)-ATPases of Ustilago maydis

, 2022
Plasma membrane H(+)-ATPases of fungi, yeasts, and plants act as proton pumps to generate an electrochemical gradient, which is essential for secondary transport and intracellular pH maintenance.
Olicón-Hernández, Dario Rafael, Melissa Vázquez-Carrada, Feldbrügge, Michael, Juan Pablo Pardo, Vázquez-Carrada, Melissa, Guadalupe Guerra-Sánchez, Dario Rafael Olicón-Hernández, Michael Feldbrügge, Guerra-Sánchez, Guadalupe, Pardo, Juan Pablo   +9 more
core   +1 more source

Unveiling contrasting iron efficiency strategies in common bean (Phaseolus vulgaris L.) genotypes under iron deficiency

Plant Biology, EarlyView.
Common bean genotypes differ in their iron acquisition through distinct Strategy I responses and root exudation patterns. Abstract Iron (Fe) deficiency in food crops, particularly on calcareous soils, limits productivity and human nutrition. This study investigated two common bean (Phaseolus vulgaris) genotypes, Guaymí (high Fe‐accumulating, HI) and ...
F. X. Rucamumihigo, U. Ludewig, A. Hernández‐Pridybailo, I. Cakmak, N. J. Maywald   +4 more
wiley   +1 more source

No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases

, 2018
In this issue of Molecular Cell, Roh et al. (2018) present a high-resolution cryo-EM structure of the nanodisc-reconstituted yeast Vo proton channel that provides important new insights into subunit arrangements and the proton translocation pathway in V ...
Stephen P. Muench, Martin van der Laan, Muench, SP, van der Laan, M   +3 more
core   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

, 2007
Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental ...
Agnes Michalczyk (13056828), Belinda Mary Hardman (13052154), J Camakaris (13278537), M Greenough (13280541), Julian Mercer (13076475), Leigh Ackland (13080843)   +5 more
core