Results 31 to 40 of about 402,722 (159)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Leone, V, Yildiz, Ö, Meier, T, Iglesias-Cans, M, Cook, G., Sarah Schulz (426341), Meier, Thomas, Sarah Schulz, Matthies, D., Meier, T. ; https://orcid.org/, Schulz, Sarah, Özkan Yildiz (244574), M. Cook, Gregory, Doreen Matthies (426343), Thomas Meier, José D. Faraldo-Gómez (426344), Faraldo-Gómez, J., José D Faraldo-Gómez, Yildiz, Ö. ; https://orcid.org/, Iglesias-Cans, Marina, Gregory M. Cook (255231), Krah, A, Alexander Krah, https://orcid.org/, Vanessa Leone, Cook, Gregory M., Yildiz, Özkan, Meier, Thomas Kurt, Alexander Krah (217992), Cook, GM, Iglesias-Cans, M., Schulz, S, Doreen Matthies, Schulz, S., Leone, Vanessa, Matthies, D, Leone, V., Marina Iglesias-Cans, Marina Iglesias-Cans (426342), Thomas Meier (244580), Gregory M Cook, Krah, Alexander, Matthies, Doreen, Faraldo-Gómez, José D., Faraldo-Gómez, JD, Vanessa Leone (266195), Ozkan Yildiz, Krah, A.   +47 more
core   +2 more sources

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Proton-translocating reactions in iDsh827.

, 2013
Proton-translocating reactions in iDsh827.
Nelli Bill (466333), Kerstin Schmidt-Hohagen (466334), Dietmar Schomburg (19141), Rene Rex (5656480)   +3 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Akzessorische Untereinheiten von Komplex I aus Yarrowia lipolytica [PDF]

, 2005
Mitochondial NADH:ubiquinone oxidoreductase (complex I) the largest multiprotein enzyme of the respiratory chain, catalyses the transfer of two electrons from NADH to ubiquinone, coupled to the translocation of four protons across the membrane.
Abdrakhmanova, Albina
core  

Proton-translocating ATPase from bovine kidney medulla: partial purification and reconstitution

, 1988
The proton-translocating ATPase that is responsible both for urinary and vacuolar acidification was partially purified from bovine kidney medulla microsomes.
S. Gluck, J. Caldwell
core   +1 more source