Results 31 to 40 of about 5,860 (202)

Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae [PDF]

, 2012
In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation.
Höfken, T, Lin, M, Kane, PM, Li, SC
core   +1 more source

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy [PDF]

Frontiers in Pharmacology, 2014
Vacuolar proton-translocating ATPase (V-ATPase) is a membrane-bound, multi-subunit enzyme that uses the energy of ATP hydrolysis to pump protons across membranes. V-ATPase activity is critical for pH homeostasis and organelle acidification as well as for generation of the membrane potential that drives secondary transporters and cellular metabolism.
Summer R. Hayek, Samuel A. Lee, Samuel A. Lee, Karlett J. Parra   +3 more
openaire   +3 more sources

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Biochemical, cytochemical localization and physiological studies on Malpighian tubules of Locusta Migratoria L. [PDF]

, 1997
Specific inhibitors of protein kinase A (PKA), Rp-cAMP, protein kinase C (PKC), chelerythrine and staurosporine, and protein phosphatase 1 and 2A okadaic acid, inhibited fluid secretion whilst corpora cardiaca (CC) extract and cAMP were found to ...
Ali Al-Fifi, Zarrag, Al-Fifi, Z.I.A.
core  

Evolutionary links between FliH/YscL-like proteins from bacterial type III secretion systems and second-stalk components of the FoF1 and vacuolar ATPases

, 2006
Bacterial type III secretion drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions. Type III secretion is driven by an ATPase that is homologous to the catalytic subunits of proton-translocating ATPases, such as the FoF1 ATPase ...
Scott A. Beatson, Bailey, Christopher M, Pallen, Mark J, Beatson, Scott A, Pallen, M. J., Christopher M. Bailey, Bailey, C. M., Beatson, S. A., Mark J. Pallen   +8 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The molecular structure of the Na+-translocating F1F0-ATPase of Acetobacterium woodii, as revealed by electron microscopy, resembles that of H+-translocating ATPases

, 1994
The Na+-translocating F1F0-ATPase of Acetobacterium woodii was examined by electron microscopy. After reconstitution into proteoliposomes, knobs typical for the F1 domain were visible on the outside of the membrane.
Mayer, Frank, Jutta Reidlinger, Reidlinger, Jutta, Frank Mayer, Volker Müller, Müller, Volker   +5 more
core   +1 more source

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Leone, V, Yildiz, Ö, Meier, T, Iglesias-Cans, M, Cook, G., Sarah Schulz (426341), Meier, Thomas, Sarah Schulz, Matthies, D., Meier, T. ; https://orcid.org/, Schulz, Sarah, Özkan Yildiz (244574), M. Cook, Gregory, Doreen Matthies (426343), Thomas Meier, José D. Faraldo-Gómez (426344), Faraldo-Gómez, J., José D Faraldo-Gómez, Yildiz, Ö. ; https://orcid.org/, Iglesias-Cans, Marina, Gregory M. Cook (255231), Krah, A, Alexander Krah, https://orcid.org/, Vanessa Leone, Cook, Gregory M., Yildiz, Özkan, Meier, Thomas Kurt, Alexander Krah (217992), Cook, GM, Iglesias-Cans, M., Schulz, S, Doreen Matthies, Schulz, S., Leone, Vanessa, Matthies, D, Leone, V., Marina Iglesias-Cans, Marina Iglesias-Cans (426342), Thomas Meier (244580), Gregory M Cook, Krah, Alexander, Matthies, Doreen, Faraldo-Gómez, José D., Faraldo-Gómez, JD, Vanessa Leone (266195), Ozkan Yildiz, Krah, A.   +47 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source