Results 21 to 30 of about 7,610 (197)

Antifungal mechanism of action of lactoferrin: Identification of H+-ATPase (P3A-type) as a new apoptotic-cell membrane receptor [PDF]

, 2016
Human lactoferrin (hLf) is a protein of the innate immune system which induces an apoptotic-like process in yeast. Determination of the susceptibility to lactoferrin of several yeast species under different metabolic conditions, respiratory activity ...
Acosta Zaldívar, Maikel, Andrés Gómez, María Teresa, Fierro Roza, José Fernando   +2 more
core   +1 more source

Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen. [PDF]

, 2016
Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex
Barta, Michael L, de la Maza, Luis M, Hefty, P Scott, Pal, Sukumar, Tifrea, Delia F   +4 more
core   +1 more source

Proton-translocating ATPase and lysosomal cystine transport.

Journal of Biological Chemistry, 1983
A proton-translocating ATPase was identified in highly purified lysosomes from Epstein-Barr virus-transformed human lymphoblasts. Activity of this ATPase caused acidification of highly purified, fluorescein isothiocyanate dextran-loaded lysosomes and correlated with the ATP-dependent efflux of lysosomal cystine.
A J, Jonas, M L, Smith, W S, Allison, P K, Laikind, A A, Greene, J A, Schneider   +5 more
openaire   +2 more sources

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules [PDF]

Biochemical Journal, 1982
Insulin-secretory granules isolated from a pancreatic islet-cell tumour by centrifugation on Percoll density gradients exhibited a membrane-associated Mg2+-dependent ATPase activity. In granule suspensions incubated in iso-osmotic media, activity was increased 2–3-fold by carbonyl cyanide p-trifluoromethoxyphenylhydrazone, the combination of ...
J C, Hutton, M, Peshavaria
openaire   +2 more sources

Subcellular distribution of the V-ATPase complex in plant cells, and localisation of the 100 kDa subunit VHA-a within the complex [PDF]

, 2004
Background Vacuolar H+-ATPases are large protein complexes of more than 700 kDa that acidify endomembrane compartments and are part of the secretory system of eukaryotic cells. They are built from 14 different (VHA)-subunits.
Kluge Christoph, Seidel Thorsten, Bolte Susanne, Sharma Shanti S, Hanitzsch Miriam, Satiat-Jeunemaitre Beatrice, Roß Joachim, Sauer Markus, Golldack Dortje, Dietz Karl-Josef   +9 more
core   +3 more sources

Kinetic analysis of proton translocation catalyzed by F₀F₁ ATPase [PDF]

FEBS Letters, 1988
Kinetic analysis of both proton translocating and steady‐state ATP hydrolytic activities catalyzed by F0F1 ATPase in submitochondrial particles were carried out over an ATP concentration range of 1–2000 μM. The results were examined in relation to the prediction based on the alternate binding change model proposed by Gresser et al. [(1982) J.
Muneyuki, Eiro, Hirata, Hajime
openaire   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Regulatory assembly of the vacuolar proton pump VOV1-ATPase in yeast cells by FLIM-FRET

, 2010
We investigate the reversible disassembly of VOV1-ATPase in life yeast cells by time resolved confocal FRET imaging. VOV1-ATPase in the vacuolar membrane pumps protons from the cytosol into the vacuole. VOV1-ATPase is a rotary biological nanomotor driven
Batisse, Claire, Boersch, Michael, Boettcher, Bettina, Ernst, Stefan, Zarrabi, Nawid   +4 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. [PDF]

, 1987
Specialized proton-secreting cells known collectively as mitochondria-rich cells are found in a variety of transporting epithelia, including the kidney collecting duct (intercalated cells) and toad and turtle urinary bladders.
Brown, D, Gluck, S, Hartwig, J
core