Results 151 to 160 of about 3,469,794 (238)

Precision Oncology via Radiotherapy‐Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang, Tanfeng Zhang, Junliang Dong, Wenjing Sun   +3 more
wiley   +1 more source

Towards ultra-fast treatments: large energy acceptance beam delivery systems and opportunities for proton beam therapy. [PDF]

Front Oncol
Yap J, Steinberg A, Norman H, Nesteruk KP, Sheehy S.   +4 more
europepmc   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, Volume 4, Issue 3, September 2026.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Proton beam therapy for patients with distal cholangiocarcinoma: a multicenter prospective registry study (Influence of age factor). [PDF]

J Radiat Res
Yamazaki H, Shibuya K, Kimoto T, Suzuki M, Murakami M, Terashima K, Iizumi T, Wakatsuki M, Ogino T, Takagi M, Araya M, Matsumoto S, Ogino H, Hashimoto T, Hojo H, Fukumitsu N, Yanagi T.   +16 more
europepmc   +1 more source

Improved Locoregional Recurrence‐Free Survival With Carbon Ion Versus Photon Radiotherapy in Locally Advanced Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Introduction Carbon ion radiotherapy (CIRT) delivers high linear energy transfer radiation with superior dose conformity compared with photon radiotherapy (PRT). However, whether these physical advantages translate into clinical benefit for locally advanced non‐small cell lung cancer (LA‐NSCLC) in the era of modern systemic therapy remains ...
Yonglong Liu, Ningyi Ma, Yaqi Li, Jing Mi, Xingwen Fan, Jian Chen, Jingfang Mao, Guoliang Jiang, Kailiang Wu   +8 more
wiley   +1 more source

Proton Beam Therapy in Gynecological Cancers: A Systematic Review of Indications, Complications, and Limitations. [PDF]

Medicina (Kaunas)
Capozzi VA, Martignon G, Scarpelli E, De Finis A, Restaino S, Vizzielli G, Berretta R.   +6 more
europepmc   +1 more source

Proton beam therapy induces protective immunity via HMGB1-dependent signaling. [PDF]

Front Public Health
Wen J, Tu X, Ren W, Wang Q, Wang Y, Guo G, Osada K, Shimokawa T, Takahashi A, Nakajima NI, Zhang S, Gu W, Li Y, Li C, Sui L, Ma L.   +15 more
europepmc   +1 more source

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor‐Specific Evidence, and Translational Roadmaps

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu, Yawei Jiao, Jiao Xue, Xiaoli Lv, Songbing Qin   +4 more
wiley   +1 more source

A novel technique of spacer implantation and proton beam therapy for hilar cholangiocarcinoma: a case report. [PDF]

Front Oncol
Yang W, Mizoe J, Wang X.
europepmc   +1 more source

Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
CF‐Paeonol, a molecular hybrid of clofibric acid and paeonol, retains lipid‐lowering activity while producing markedly less hepatic injury than clofibrate (CF) in mice. Its benefits are accompanied by improved bile acid homeostasis, reduced oxidative stress and inflammation, decreased YY1 expression, and increased FXR expression, supporting molecular ...
Haoyu Tu, Ling Ding, Jing Zheng, Yichen Yang, Xin Chen, Yumiao Song, Xinyi Shi, Chuwen Wang, Xinya Xu, Jiping Liu, Yundong Xie   +10 more
wiley   +1 more source