Results 51 to 60 of about 70,358 (296)

Precision-Engineered Construction of Proton-Conducting Metal–Organic Frameworks

Nano-Micro Letters
Highlights The effects of the size structure and stability of metal–organic frameworks (MOFs) on proton conduction are comprehensively summarized. Advanced strategies for constructing proton conduction MOFs are critically discussed.
Liyu Zhu, Hongbin Yang, Ting Xu, Feng Shen, Chuanling Si   +4 more
doaj   +1 more source

Synthesis and proton conduction properties of lanthanide amino-sulfophosphonates [PDF]

, 2016
Crystalline acid-functionalized metal phosphonates are potential candidates as proton conducting electrolytes. Their frameworks can be chemically modified to contain proton carriers such as acidic groups (P-OH; -SO3H, -COOH,…) and guest molecules (H2O ...
Bazaga-García, Montse, Cabeza-Diaz, Aurelio, Colodrero, Rosario M.P., Losilla, E. R., Olivera-Pastor, Pascual, Salcedo, Inés R., Villemin, Didier   +6 more
core  

First-principles investigation of polarization and ion conduction mechanisms in hydroxyapatite

, 2017
We report first-principles simulation of polarization mechanisms in hydroxyapatite to explain the underlying mechanism behind the reported ion conductivities and polarization under electrical poling at elevated temperatures.
Kasamatsu, Shusuke, Sugino, Osamu
core   +1 more source

Onsager's Wien Effect on a Lattice [PDF]

, 2013
The Second Wien Effect describes the non-linear, non-equilibrium response of a weak electrolyte in moderate to high electric fields. Onsager's 1934 electrodiffusion theory along with various extensions has been invoked for systems and phenomena as ...
Lyon Cedex, P. C. W. Holdsworth, R. Moessner, S. T. Bramwell, V. Kaiser   +4 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Secondary water pore formation for proton transport in a ClC exchanger revealed by an atomistic molecular dynamics simulation [PDF]

, 2008
Several prokaryotic ClC proteins have been demonstrated to function as exchangers that transport both chloride ions and protons simultaneously in opposite directions.
Won Ho Jo, Youn Jo Ko
core   +1 more source

Enhancement of the conductivity of Ba2In2O5 through phosphate doping [PDF]

, 2010
In this paper, we demonstrate the successful incorporation of phosphate into Ba2In2O5, which leads to the conversion from an orthorhombic to a cubic unit cell.
Hussey, L, Orera, A, Shin, J.F., Slater, P.R.   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Nanocrystalline Surface Layer of WO₃ for Enhanced Proton Transport during Fuel Cell Operation

Crystals, 2021
High ionic conductivity in low-cost semiconductor oxides is essential to develop electrochemical energy devices for practical applications. These materials exhibit fast protonic or oxygen-ion transport in oxide materials by structural doping, but their ...
Xiang Song, Weiqing Guo, Yuhong Guo, Naveed Mushtaq, M. A. K. Yousaf Shah, Muhammad Sultan Irshad, Peter D. Lund, Muhammad Imran Asghar   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source