Results 51 to 60 of about 21,338 (294)

Template-directed proton conduction pathways in a coordination framework [PDF]

open access: yes, 2014
We present a strategy for creating coordination frameworks exhibiting proton conduction with thermal stability. The coordination framework, where template cations link 1-D chains via hydrogen bonds, has dynamic hydrogen bond networks where protons move ...
Chen, Wenqian   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A Study on the Synthesis and Proton Transport Behavior of Multilayered ZSM-5 Zeolite Nanosheet Membranes Laminated on Polymer Substrates

open access: yesMembranes, 2023
Single crystalline ZSM-5 ZNs with thicknesses around 6 nm were obtained by secondary growth of silicalite nanoparticles using diquaternary bis-1,5(tripropyl ammonium) pentamethylene diiodide (dC5) as a structure-directing agent (SDA).
Zishu Cao   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Investigating Proton Conduction using Guest-Loaded Metal-Organic Frameworks [PDF]

open access: yes, 2019
Two Metal-Organic Frameworks (MOFs), ZIF-65 and ZIF-90 were loaded with phosphate esters and investigated for their abilities as proton conductors at temperatures ranging from 23ºC to 200ºC, with the goal being the achievement of superprotonic conduction
Lin, Giselle
core   +1 more source

Synergistic Proton and Oxygen Ion Transport in Fluorite Oxide-Ion Conductor

open access: yesEnergy Material Advances
Current perovskite oxide electrolytes, i.e., acceptor-doped Ba(Ce,Zr)O3-δ, exhibit proton conductivity ranging from 10−3 to 10−2 S cm−1 at 600 °C for protonic ceramic fuel cells (PCFCs), which rely on the structural defects.
Yong Yu   +7 more
doaj   +1 more source

Construction of hydrogel composites with superior proton conduction and flexibility using a new POM-based inorganic–organic hybrid

open access: yesPolyoxometalates, 2022
Polyoxometalates (POMs) have attracted extensive interests as solid-state proton conductors due to their high conductivity and good thermal stability.
Yuxin Wang   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Precision-Engineered Construction of Proton-Conducting Metal–Organic Frameworks

open access: yesNano-Micro Letters
Highlights The effects of the size structure and stability of metal–organic frameworks (MOFs) on proton conduction are comprehensively summarized. Advanced strategies for constructing proton conduction MOFs are critically discussed.
Liyu Zhu   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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