Results 61 to 70 of about 108,847 (296)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Proton conductivity and luminiscence properties of lanthanide aminotriphosphonates [PDF]

, 2016
Metal phosphonates are multifunctional solids with tunable properties, such as internal H-bond networks, and high chemical and thermal stability [1]. In the present work, we describe the synthesis, structural characterization, luminescent properties ...
Angeli, Giasemi K., Bazaga-García, Montse, Cabeza-Diaz, Aurelio, Choquesillo-Lazarte, Duane, Demadis, Konstantinos D., Hix, Gary B., Losilla, E. R., Olivera-Pastor, Pascual, Papathanasiou, Konstantinos E., Salcedo, Inés R.   +9 more
core  

Nuclear medium cooling scenario in the light of new Cas A cooling data and the 2 M_sun pulsar mass measurements

, 2013
Recently, Elshamounty et al. performed a reanalysis of the surface temperature of the neutron star in the supernova remnant Cassiopeia A on the basis of Chandra data measured during last decade, and added a new data point. We show that all reliably known
Blaschke, D., Grigorian, H., Voskresensky, D. N.   +2 more
core   +1 more source

Electrical Conductivity at the Core of a Magnetar [PDF]

, 2001
An expression for the electrical conductivity at the core of a magnetar is derived using Boltzmann kinetic equation with the relaxation time approximation.
ASHOK GOYAL, Chakrabarty S., Ghosh T., KANUPRIYA GOSWAMI, SANCHAYITA GHOSH, SOMENATH CHAKRABARTY, SUTAPA GHOSH, van Paradihs J.   +7 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Viscous fluid dynamical calculation of the reaction 12C(85 MeV/nucleon) + 197Au [PDF]

, 2006
Proton spectra have been calculated for the reaction 12C(85 MeV/nucleon) + 197Au using a three-dimensional hydrodynamical model with viscosity and thermal conductivity and final thermal breakup. The theoretical results are compared to recent data.
Buchwald, Gerd, Graebner, Gerhard, Greiner, Walter, Maruhn, Joachim, Stöcker, Horst, Theis, Jürgen   +5 more
core  

Geomagnetic disturbances on ground associated with particle precipitation during SC [PDF]

, 2010
We have examined several cases of magnetosphere compression by solar wind pressure pulses using a set of instruments located in the noon sector of auroral zone. We have found that the increase in riometric absorption (sudden commencement absorption, SCA)
Honary, F., Kozlovsky, A., Safargaleev, V., Turunen, T., Voronin, A.   +4 more
core   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Novel PVA/La2Ce2O7 hybrid nanocomposite membranes for application in proton exchange membrane fuel cells [PDF]

Hydrogen, Fuel Cell & Energy Storage, 2014
Proton exchange membrane fuel cells (PEMFCs) are electrochemical devices that show the highest power densities compared to the other type of fuel cell.
Mehran Javanbakht, Khadijeh Hooshyari, Morteza Enhessari, Hossein Beydaghi   +3 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source