Results 191 to 200 of about 2,542,698 (234)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Dose calculations for clinical proton broad beams by GEANT4

Dose calculations for clinical proton broad beams by GEANT4
openaire   +1 more source

Macro Monte Carlo for dose calculation of proton beams

Physics in Medicine and Biology, 2013
Although the Monte Carlo (MC) method allows accurate dose calculation for proton radiotherapy, its usage is limited due to long computing time. In order to gain efficiency, a new macro MC (MMC) technique for proton dose calculations has been developed. The basic principle of the MMC transport is a local to global MC approach.
Fix, Michael, Frei, Daniel, Volken, Werner, Born, Ernst Johann, Aebersold, Daniel Matthias, Manser, Peter   +5 more
openaire   +5 more sources

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Proton Dose Calculation With Transformer: Transforming Spot Map to Dose

Medical Physics
Abstract Background Conventional proton dose calculation methods are either time‐ and resource‐intensive, like Monte Carlo (MC) simulations, or they sacrifice accuracy, as seen with analytical methods. This trade‐off between computational efficiency and accuracy highlights the need for improved
Jing Qian
exaly   +3 more sources

Proton dose calculations in homogeneous media [PDF]

, 2022
In this study, a proton pencil beam dose calculation algorithm was developed for a parallel, monoenergetic beam incident on a homogeneous water phantom.
Chapman, Jr., John Wesley, John Chapman, Jr., null null   +2 more
openaire   +2 more sources

A pencil beam algorithm for proton dose calculations

Physics in Medicine and Biology, 1996
The sharp lateral penumbra and the rapid fall-off of dose at the end of range of a proton beam are among the major advantages of proton radiation therapy. These beam characteristics depend on the position and characteristics of upstream beam-modifying devices such as apertures and compensating boluses.
L. Hong, M. Goitein, BUCCIOLINI, MARTA, R. Comiskey, B. Gottschalk, S. Rosenthal, C. Serago, M. Urie   +7 more
openaire   +3 more sources

A Monte Carlo dose calculation algorithm for proton therapy

Medical Physics, 2004
A Monte Carlo (MC) code (VMCpro) for treatment planning in proton beam therapy of cancer is introduced. It is based on ideas of the Voxel Monte Carlo algorithm for photons and electrons and is applicable to human tissue for clinical proton energies. In the present paper the implementation of electromagnetic and nuclear interactions is described.
Matthias, Fippel, Martin, Soukup
openaire   +2 more sources

Proton loss model for therapeutic beam dose calculations

Medical Physics, 2000
A transport algorithm called the proton loss (PL) model is developed for proton pencil beams of therapeutic energies. The PL model takes into account inelastic nuclear reactions, pathlength straggling, and energy-loss straggling and predicts the 3D dose distribution from a proton pencil beam.
G A, Sandison, A V, Chvetsov
openaire   +2 more sources

Benchmarking analytical calculations of proton doses in heterogeneous matter

Medical Physics, 2005
A proton dose computational algorithm, performing an analytical superposition of infinitely narrow proton beamlets (ASPB) is introduced. The algorithm uses the standard pencil beam technique of laterally distributing the central axis broad beam doses according to the Moliere scattering theory extended to slablike varying density media.
George, Ciangaru, Jerimy C, Polf, Martin, Bues, Alfred R, Smith   +3 more
openaire   +2 more sources