Results 201 to 210 of about 130,730 (348)

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Tegoprazan Versus Proton Pump Inhibitors for Erosive Esophagitis: A Meta-Analysis of Noninferiority Randomized Controlled Trials. [PDF]

JGH Open
Bhatti MI, Safiullah M, Ijaz A, Mehmood Q, Shahid IF, Shahriar Z.   +5 more
europepmc   +1 more source

975 – Proton-Pump Inhibitors May Enhance Intestinal Permeability Via Dysbiosis of Gut Microbiota Under Stressed Conditions in Mice

, 2019
Shingo Takashima, Fumio Tanaka, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara   +10 more
openalex   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Proton Pump Inhibitors and Histamine-2 Receptor Antagonists in Spinal Fusion: A Systematic Review. [PDF]

Global Spine J
Frappa N, Chernov D, Alben MG, Dillon M, Papalia AG, Riley R, Troiani Z, Lucasti C.   +7 more
europepmc   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Analysis of infection-related adverse events induced by proton pump inhibitors based on the FAERS and JADER databases. [PDF]

Medicine (Baltimore)
Hu S, Yu H, Liu Z.
europepmc   +1 more source

Substantive Methodological Limitations and Unexplored Causal Pathways in the Association Between Proton Pump Inhibitors and Adverse Events in Chronic Kidney Disease: A Critical Appraisal [PDF]

Shuang Wang, DuJiang Yang, Jiexiang Yang, GuoYou Wang   +3 more
openalex   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

Proton pump inhibitors and gut microbiota dysbiosis: insights into the pathogenesis of ulcerative colitis. [PDF]

Front Microbiol
Cao F, Liu Z, Liu S, Liu Y, Qi Y, Cheng Y, Wang Y, Xu Y.   +7 more
europepmc   +1 more source