Results 11 to 20 of about 5,204,838 (351)

Paediatric proton therapy

open access: yesThe British Journal of Radiology, 2019
Proton beam therapy is a highly conformal form of radiation therapy, which currently represents an important therapeutic component in multidisciplinary management in paediatric oncology. The precise adjustability of protons results in a reduction of radiation-related long-term side-effects and secondary malignancy induction, which is of particular ...
Thomas, Heike, Timmermann, Beate
openaire   +4 more sources

A review of proton therapy – Current status and future directions

open access: yesPrecision Radiation Oncology, 2022
The original rationale for proton therapy was its highly conformal depth‐dose distributions compared to photons, which allow greater sparing of normal tissues and escalation of tumor doses, thus potentially improving outcomes.
R. Mohan
semanticscholar   +1 more source

Image-Guided Proton Therapy: A Comprehensive Review

open access: yesCancers, 2023
Simple Summary In proton therapy, there is a sharp peak in the delivered dose followed by a rapid falloff, known as the Bragg peak, which is not present in photons.
Shelby A. Lane, J. Slater, Gary Y. Yang
semanticscholar   +1 more source

A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs

open access: yesCancers, 2023
Simple Summary The increasing global demand and accessibility for proton beam therapy has been fueled by its recognised clinical benefits over traditional radiotherapy, primarily its ability to precisely target tumors while sparing more healthy tissue ...
Mel McIntyre   +3 more
semanticscholar   +1 more source

Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Oropharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy

open access: yesJAMA Network Open, 2022
This cohort study compares the toxic effects and oncologic outcomes associated with intensity-modulated radiation therapy (IMRT) vs intensity-modulated proton therapy (IMPT) among adult patients with oropharyngeal carcinoma.
Irini Youssef   +23 more
semanticscholar   +1 more source

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

open access: yesNature Communications, 2022
Nanoparticle-based radioenhancement is a promising strategy for extending the therapeutic ratio of radiotherapy. While (pre)clinical results are encouraging, sound mechanistic understanding of nanoparticle radioenhancement, especially the effects of ...
Lukas R. H. Gerken   +10 more
semanticscholar   +1 more source

Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges

open access: yesCancers, 2022
Simple Summary Proton therapy is a promising type of radiation therapy used to destroy tumor cells. It has the potential to further improve the outcomes for patients with head and neck cancer since it allows to minimize the radiation dose to vital ...
S. Nuyts   +9 more
semanticscholar   +1 more source

A Critical Review of LET-Based Intensity-Modulated Proton Therapy Plan Evaluation and Optimization for Head and Neck Cancer Management

open access: yesInternational Journal of Particle Therapy, 2021
In this review article, we review the 3 important aspects of linear-energy-transfer (LET) in intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management.
W. Deng   +8 more
semanticscholar   +1 more source

Radiosensitization Effect of Gold Nanoparticles in Proton Therapy

open access: yesFrontiers in Public Health, 2021
The number of proton therapy facilities and the clinical usage of high energy proton beams for cancer treatment has substantially increased over the last decade.
C. Cunningham   +5 more
semanticscholar   +1 more source

National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

open access: yesInternational Journal of Particle Therapy, 2021
In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose,
J. Langendijk   +13 more
semanticscholar   +1 more source

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