Results 201 to 210 of about 5,204,838 (351)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Experimental design and control methods for dose rate optimization in a synchrotron-based proton therapy beamline. [PDF]

Precis Radiat Oncol
Tang J, Liu D, Mathew J, Campelo S, Bronk L, Taylor P, Li Y, Guan F.   +7 more
europepmc   +1 more source

A Comparison of Biological Dose Estimates in Proton and Carbon Ion Therapy Based on Averaged and Full Linear Energy Transfer Spectra

, 2015
Eivind Rørvik
openalex   +1 more source

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source

Synthetic computed tomography techniques for adaptive proton therapy in head and neck cancers. [PDF]

Phys Imaging Radiat Oncol
Kaushik S, Vatterodt N, Ödén J, Fredriksson A, Korreman SS, Toma-Dasu I.   +5 more
europepmc   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Proton radiography interpretation with artificial intelligence for treatment deviation detection in proton therapy. [PDF]

Phys Imaging Radiat Oncol
Perotti Bernardini G, Galapon A, Guterres Marmitt G, Free J, van Ooijen P, Langendijk J, Both S.   +6 more
europepmc   +1 more source

Enhancement of Proton Therapy Efficiency by Noble Metal Nanoparticles Is Driven by the Number and Chemical Activity of Surface Atoms

, 2021
Sandra Zwiehoff, Jacob Johny, Carina Behrends, Alina Landmann, Florian Mentzel, Christian Bäumer, K. Kroeninger, Christoph Rehbock, Beate Timmermann, Stephan Barcikowski   +9 more
openalex   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Clinical implementation of intensity modulated proton therapy for testicular seminoma. [PDF]

Acta Oncol
Rønde HS, Kallehauge JF, Høyer M, Als AB, Agerbæk M, Lauritsen J, Petersen PM, Dysager L, Kronborg CJS.   +8 more
europepmc   +1 more source