Results 81 to 90 of about 266,081 (333)

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Standard operating procedure (SOP) for immobilisation, scanning, verification and treatment of breast cancer patients undergoing proton beam therapy

Technical Innovations & Patient Support in Radiation Oncology
The use of proton beam therapy (PBT) for breast cancer is not currently included for standard consideration on the NHS England indication list. However, there are occasions where the use of PBT may be approved in the United Kingdom (UK), such as breast ...
Kathryn Osborn, Jaymisha Davda, Rita Simoes, Michael O’Connor, Olivia Willis, Sarah Gulliford, Syed Ali Moinuddin, Turmi Patel, Sarah Petty, Mahbubl Ahmed, Thomas Richards, Sairanne Wickers   +11 more
doaj   +1 more source

RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model

Radiation Oncology, 2020
Background We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses ...
Liwen Zhang, Weiwei Wang, Jiyi Hu, Jiade Lu, Lin Kong   +4 more
doaj   +1 more source

MCHIT - Monte Carlo model for proton and heavy-ion therapy

, 2007
We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2).
Greiner, Walter, Mishustin, Igor, Pshenichnov, Igor   +2 more
core   +1 more source

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, EarlyView.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Proton therapy

Biomedical Journal, 2015
Kuniaki Katsui, Tomoaki Okimoto, Susumu Kanazawa   +2 more
  +6 more sources

Respiratory-gated proton beam therapy for intrahepatic cholangiocarcinoma without fiducial markers

Radiation Oncology
Background Intrahepatic cholangiocarcinoma (ICC) is a challenging primary liver cancer with a poor prognosis, especially in unresectable cases. Traditional palliative irradiation is limited in reducing liver doses.
Akihito Okubo, Sae Matsumoto, Hiroyasu Tamamura, Yoshitaka Sato, Satoko Asahi, Hitoshi Tatebe, Kazutaka Yamamoto, Keiichiro Matsushita, Makoto Sasaki, Yoshikazu Maeda, Yuji Tameshige, Hajime Sunagozaka, Hiroyuki Aoyagi, Satoshi Shibata, Shigeyuki Takamatsu, Satoshi Kobayashi   +15 more
doaj   +1 more source

Implementation of proton therapy in the portuguese context of radiotherapy [PDF]

, 2013
Cancer is a national and international health care concern. It’s important to find strategies for early diagnosis as well as for the optimization of the various therapeutic options currently existing in Portugal.
Lança, Cristina, Monsanto, Fátima
core  

Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy

, 2021
A.M.M. Leite, Maria Grazia Ronga, M. Giorgi, Yoann Ristic, Y. Perrot, F. Trompier, Yolanda Prezado, G. Créhange, Ludovic De Marzi   +8 more
openalex   +2 more sources