Results 81 to 90 of about 5,021,050 (358)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Clinical outcomes of image-guided proton therapy for histologically confirmed stage I non-small cell lung cancer

Radiation Oncology, 2018
Background Two prospective phase II trials were designed to assess the efficacy and safety of image-guided proton therapy (IGPT) for either medically inoperable or operable stage I non-small cell lung cancer (NSCLC). The present study reports the interim
Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Yukiko Hattori, Shingo Hashimoto, Toshiyuki Toshito, Kensuke Hayashi, Kenji Akita, Fumiya Baba, Katsumi Nakamae, Jun-etsu Mizoe, Yuta Shibamoto   +11 more
doaj   +1 more source

Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer. [PDF]

, 2010
The objective was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in ...
Huh, Soon N, Liang, Yun, Mell, Loren K, Mundt, Arno J, Nichols, R Charles, Song, William Y, Watkins, W Tyler, White, Greg   +7 more
core   +2 more sources

The Future of Proton Therapy

, 2021
Proton therapy is increasing in utilization worldwide at a rapid rate. With process improvements in costs, footprints, and continued advances in the delivery of care, including intensity modulation and image guidance, proton therapy may evolve into standard treatment with photon radiation therapy.
Allison Sacher, Michael Anderegg, Kevin C. O’Connor, James Shen, Fenghong Liu, Linda Ding, Ameer L. Elaimy, Eric Ko, Jack Bailey, T.J. FitzGerald, Harry Bushe, Daniel Han, I-Lin Kuo, Paul Rava, Jonathan Saleeby, Suhong Yu, Janaki Moni, Carla Bradford, M. Giulia Cicchetti, Christopher Riberdy, Shirin Sioshansi, Maryann Bishop-Jodoin, Yankhua Fan   +22 more
openaire   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Predicting the safety and efficacy of butter therapy to raise tumour pHe: an integrative modelling study [PDF]

, 2012
Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment ...
A Ibrahim Hashim, A Silva, A Singh, A Vander, D Groothuis, E A Gaffney, E Freireich, ED Michelakis, G Helmlinger, I de Brito-Ashurst, I F Robey, IF Robey, IR Robey, J Lemann, K Hoang, K Smallbone, N K Martin, NK Martin, O Warburg, P K Maini, PA Schornack, R A Gatenby, R J Gillies, RA Gatenby, RA Gatenby, RA Gatenby, RA Gatenby, RF Pitts, RJ Gillies, RK Jain, S Bonnet, S Reagan-Shaw, SS Gambhir, T DuBose, T Nijenhuis   +34 more
core   +1 more source

A Bayesian Inverse Approach to Proton Therapy Dose Delivery Verification [PDF]

arXiv, 2023
This study presents a proof-of-concept for a novel Bayesian inverse method in a one-dimensional setting, aimed at proton beam therapy treatment verification. Our methodology is predicated on a hypothetical scenario wherein strategically positioned sensors detect prompt-{\gamma}'s emitted from a proton beam when it interacts with defined layers of ...
arxiv  

Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy

Cancer/Radiothérapie, 2019
In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so
Consuelo Guardiola, Consuelo Guardiola, Annalisa Patriarca, T. Schneider, T. Schneider, H. Mammar, Frederic Pouzoulet, Yolanda Prezado, Yolanda Prezado, Rémi Dendale, L. De Marzi, L. De Marzi, Catherine Nauraye, P. Lansonneur   +13 more
openaire   +7 more sources

AAPM task group 224: Comprehensive proton therapy machine quality assurance.

Medical Physics (Lancaster), 2019
PURPOSE  Task Group (TG) 224 was established by the American Association of Physicists in Medicine's Science Council under the Radiation Therapy Committee and Work Group on Particle Beams.
B. Arjomandy, P. Taylor, C. Ainsley, S. Safai, N. Sahoo, M. Pankuch, J. Farr, Sung Yong Park, E. Klein, J. Flanz, E. Yorke, D. Followill, Y. Kase   +12 more
semanticscholar   +1 more source

Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver [PDF]

, 2013
Proton relative biological effectiveness (RBE) is known to depend on the (alpha/beta)(x) of irradiated tissues, with evidence of similar to 60% variation over (alpha/beta)(x) values from 1-10 Gy.
Carabe, Alejandro, Espana Palomares, Samuel, Grassberger, Clemens, Paganetti, Harald   +3 more
core   +1 more source