Results 81 to 90 of about 2,630,925 (302)
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
A functional correlate of severity in alternating hemiplegia of childhood
Neurobiology of Disease, 2015 Objective: Mutations in ATP1A3, the gene that encodes the α3 subunit of the Na+/K+ ATPase, are the primary cause of alternating hemiplegia of childhood (AHC).
Melody Li +6 more
doaj +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Strategies for enhancing proton conductivity in perovskites: A review
Journal of Chemical ResearchProton-conductive perovskite materials are promising platforms for advanced electrochemical devices, including fuel cells, electrolyzers, and sensors, due to their mixed ionic–electronic transport properties.
Dham O. Alshamary +2 more
doaj +1 more source
Analysis of proton and electron transport impedance of a PEM fuel cell in H2/N2 regime
Electrochemical Science Advances, 2021 Analytical expressions for impedance of proton and electron transport in the cathode catalyst layer of a PEM fuel cell operating in H2/N2 regime are derived.
Andrei Kulikovsky
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Proton-Coupled Electron Transfer Drives Long-Range Proton Translocation in Bioinspired Systems
, 2019 Proton-coupled electron transfer (PCET) combines the movement of fundamental charged species to form an essential link between electron- and proton-transport reactions in bioenergetics and catalysis in general.
Joshua J. Goings (1474561) +19 more
core +1 more source
Tripeptide binding in a proton‐dependent oligopeptide transporter [PDF]
FEBS Letters, 2018 Proton‐dependent oligopeptide transporters (POTs) are important for the uptake of di‐/tripeptides in many organisms and for drug transport in humans. The binding mode of dipeptides has been well described. However, it is still debated how tripeptides are recognized. Here, we show that tripeptides of the sequence Phe‐Ala‐Xxx bind with similar affinities
Martinez Molledo, Maria +2 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
Small ScienceReversible protonic ceramic cells (RePCCs) promise integration with renewable energy, supporting sustainable energy systems. RePCC performance hinges on the air electrode activity, where optimal proton, oxygen, and electron transport are essential ...
Na Yu +6 more
doaj +1 more source