Results 61 to 70 of about 164,176 (301)

Electrochemical Detection of Ethanol in Air Using Graphene Oxide Nanosheets Combined with Au-WO₃

Sensors, 2022
Detection, monitoring, and analysis of ethanol are important in various fields such as health care, food industries, and safety control. In this study, we report that a solid electrolyte gas sensor based on a proton-conducting membrane is promising for ...
Aynul Sakinah Ahmad Fauzi, Nur Laila Hamidah, Shota Kitamura, Taiga Kodama, Kosuke Sonda, Ghina Kifayah Putri, Takeshi Shinkai, Muhammad Sohail Ahmad, Yusuke Inomata, Armando T. Quitain, Tetsuya Kida   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Membrane Lipid Composition Influences the Hydration of Proton Half-Channels in F_oF₁-ATP Synthase

Life, 2023
The membrane lipid composition plays an important role in the regulation of membrane protein activity. To probe its influence on proton half-channels’ structure in FoF1-ATP synthase, we performed molecular dynamics simulations with the bacterial protein ...
Leonid A. Ivontsin, Elena V. Mashkovtseva, Yaroslav R. Nartsissov   +2 more
doaj   +1 more source

Voltage dependence of proton pumping by bacteriorhodopsin mutants with altered lifetime of the m intermediate

, 2013
The light-driven proton pump bacteriorhodopsin (BR) from Halobacterium salinarum is tightly regulated by the [H+] gradient and transmembrane potential.
Friedrich, Thomas, Éva Lörinczi, Sven Geibel, Thomas Friedrich, Geibel, Sven, Bamberg, Ernst, Lörinczi, Èva, Ernst Bamberg   +7 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Kinetics of proton transport into influenza virions by the viral M2 channel.

PLoS ONE, 2012
M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle.
Tijana Ivanovic, Rutger Rozendaal, Daniel L Floyd, Milos Popovic, Antoine M van Oijen, Stephen C Harrison   +5 more
doaj   +1 more source

Electrostatic Potentials Caused by the Release of Protons from Photoactivated Compound Sodium 2-Methoxy-5-nitrophenyl Sulfate at the Surface of Bilayer Lipid Membrane

Membranes, 2023
Lateral transport and release of protons at the water–membrane interface play crucial roles in cell bioenergetics. Therefore, versatile techniques need to be developed for investigating as well as clarifying the main features of these processes at the ...
Valerij S. Sokolov, Vsevolod Yu. Tashkin, Darya D. Zykova, Yulia V. Kharitonova, Timur R. Galimzyanov, Oleg V. Batishchev   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Molecular dynamics study of the effect of wettability of the carbon support on proton transport in Nafion ionomer thin films

Journal of Thermal Science and Technology, 2016
Molecular dynamics simulations were carried out to elucidate the effect of the wettability of the carbon support used for Nafion ionomer thin films on proton transport in the ionomer, which is related to the power density of polymer electrolyte fuel ...
Joji AOCHI, Takuya MABUCHI, Takashi TOKUMASU   +2 more
doaj   +1 more source