Results 51 to 60 of about 164,176 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modelling the Proton-Conductive Membrane in Practical Polymer Electrolyte Membrane Fuel Cell (PEMFC) Simulation: A Review

Membranes, 2020
Theoretical models used to describe the proton-conductive membrane in polymer electrolyte membrane fuel cells (PEMFCs) are reviewed, within the specific context of practical, physicochemical simulations of PEMFC device-scale performance and ...
Edmund J. F. Dickinson, Graham Smith
doaj   +1 more source

Srna - Monte Carlo codes for proton transport simulation in combined and voxelized geometries [PDF]

Nuclear Technology and Radiation Protection, 2002
This paper describes new Monte Carlo codes for proton transport simulations in complex geometrical forms and in materials of different composition. The SRNA codes were developed for three dimensional (3D) dose distribution calculation in proton therapy ...
Ilić Radovan D., Lalić Darko, Stanković Srboljub J.   +2 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

A 2023 update on the performance of ionic-liquid proton-exchange-membrane fuel cells

Frontiers in Energy Research, 2023
A mini-review is provided of the literature concerning the performance of proton-exchange-membrane fuel cells (PEMFCs) containing (immobilized) ionic liquids as possible electrolytes, focusing on papers reporting performance metrics (power and current ...
Allan L. L. East, Cuong M. Nguyen, Rolf Hempelmann   +2 more
doaj   +1 more source

Transport of Solar Wind Fluctuations: A Two-Component Model

, 2011
We present a new model for the transport of solar wind fluctuations which treats them as two interacting incompressible components: quasi-two-dimensional turbulence and a wave-like piece.
Matthaeus, William H., P. A. Isenberg, Breech, B., Isenberg, P. A., Matthaeus, W. H., C. W. Smith, Smith, C. W., Oughton, Sean, S. Oughton, Smith, Charles W., W. H. Matthaeus, Oughton, S., B. Breech, Breech, Ben   +13 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analysis of proton and electron transport impedance of a PEM fuel cell in H2/N2 regime

Electrochemical Science Advances, 2021
Analytical expressions for impedance of proton and electron transport in the cathode catalyst layer of a PEM fuel cell operating in H2/N2 regime are derived.
Andrei Kulikovsky
doaj   +1 more source

Molecular Dynamics Simulation of Complex Reactivity with the Rapid Approach for Proton Transport and Other Reactions (RAPTOR) Software Package. [PDF]

J Phys Chem B
Simulating chemically reactive phenomena such as proton transport on nanosecond to microsecond and beyond time- scales is a challenging task. Ab initio methods are unable to currently access these timescales routinely, and traditional molecular dynamics ...
Kaiser S, Yue Z, Peng Y, Nguyen TD, Chen S, Teng D, Voth GA.   +6 more
europepmc   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source