Results 61 to 70 of about 168,635 (283)

Key Mechanistic Features in Palladium-Catalyzed Methylcyclopropanation of Norbornenes With Vinyl Bromides: Insights From DFT Calculations

Frontiers in Chemistry, 2019
DFT calculations were performed to elucidate mechanistic details of an unusual palladium-catalyzed methylcyclopropanation from [2 + 1] cycloadditions of (Z)-2-bromovinylbenzene and endo-N-(p-tolyl)-norbornenesuccinimide.
Fang Ying, Fang Ying, Yutong Zhang, Chuyue Xiang, Zhijun Song, Hujun Xie, Weiliang Bao   +6 more
doaj   +1 more source

Modulation of internuclear communication in multinuclear Ruthenium(II) polypyridyl complexes [PDF]

, 2003
The syntheses and characterisation of a series of mononuclear and dinuclear ruthenium polypyridyl complexes based on the bridging ligands 1,3-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 1,4-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 2,5-bis-[
Adrian Guckian, de Wolf, Frances Weldon, Johannes G. Vos, Wesley R. Browne   +4 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Resonance Raman Characterization of the Peroxo and Hydroperoxo Intermediates in Cytochrome P450 [PDF]

, 2008
Resonance Raman (RR) studies of intermediates generated by cryoreduction of the oxyferrous complex of the D251N mutant of cytochrome P450cam (CYP101) are reported.
Denisov, Ilia G., Kincaid, James R., Mak, Piotr J., Makris, Thomas M., Sligar, Stephen G.   +4 more
core   +1 more source

Infrared spectroscopy of phytochrome and model pigments [PDF]

, 1990
Fourier-transform infrared difference spectra between the red-absorbing and far-red-absorbing forms of oat phytochrome have been measured in H2O and 2H2O. The difference spectra are compared with infrared spectra of model compounds, i.e. the (5Z,10Z,15Z)-
Bagley K., Bagley K. A., Braiman M. S., Braslavsky S. E., Brock H., Cavaleiro J. A. S., Chai Y.-G., Eilfeld P., Engelhard M., Falk H., Farrens D. L., Fodor S. P. A., Furuya M., Ganter U. M., Grimm R., Grombein S., Holt R. E., Hsieh Y.-Z., Kendrick R. E., Kufer W., Lagarias J. C., Lagarias J. C., Lagarias J. C., Margulies L., Margulies L., Margulies L., Mathies R. A., Moon D.-K., Oseroff A. R., Rospendowski B. N., Rothschild K. J., Rudiger W., Sarkar H. K., Sawatzki J., Scheer H., Scheer H., Schendel R., Schirmer T., Schneider S., Shropshire W., Siebert F., Siebert F., Siebert F., Sulkes M., Szalontai B., Thummler F.   +45 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Crystal structure of bis[bis(4-azaniumylphenyl) sulfone] tetranitrate monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, the hydrated tetra(nitrate) salt of dapsone (4,4′-diaminodiphenylsulfone), 2C12H14N2O2S2+·4NO3−·H2O {alternative name: bis[bis(4,4′-diazaniumylphenyl) sulfone] tetranitrate monohydrate}, the cations are conformationally similar ...
Amani Hind Benahsene, Lamia Bendjeddou, Hocine Merazig   +2 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Molecular properties of a viral heliorhodopsin, V2HeR2

Biophysics and Physicobiology
Heliorhodopsin (HeR) is a family of microbial rhodopsin discovered in 2018, whose genes are found from archaea, bacteria, unicellular eukaryotes, and giant viruses.
Ritsu Mizutori, Kota Katayama, Masae Konno, Keiichi Inoue, Oded Béjà, Hideki Kandori   +5 more
doaj   +1 more source

Protonation Equilibria of L-Aspartic, Citric and Succinic Acids in Anionic Micellar Media

E-Journal of Chemistry, 2009
The impact of sodium lauryl sulphate (SLS) on the protonation equilibria of L-aspartic acid, citric acid and succinic acid has been studied in various concentrations (0.5-2.5% w/v) of SLS solution maintaining an ionic strength of 0.16 mol dm-3 at 303 K ...
P. Srinivasa Rao, B. Srikanth, V. Samba Siva Rao, C. Kamala Sastry, G. Nageswara Rao   +4 more
doaj   +1 more source