Results 191 to 200 of about 92,683 (284)

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

The dual role of intestinal parasites in shaping human gut microbiota: distinguishing helminthic and protozoan dynamics. [PDF]

Gut Pathog
Sidi Omar SFN, Ngui R, Jinam T, Jiee SF, Lim HS, Divis PCS, Bilung LM, Lim YAL.   +7 more
europepmc   +1 more source

Nutritional Strategies for Methane, Nitrogen, and Phosphorus Mitigation in Ruminants: Mechanisms, Applications, and Regional Adaptations. [PDF]

Microorganisms
Wang Z, Wang M, Su H, Shi J, Dai S, Zhang R, Wu D.   +6 more
europepmc   +1 more source

Beyond the Cascade Dams: Scale-Dependent Effects on Zooplankton Stability in River Ecosystems. [PDF]

Ecol Evol
Jiang X, Zhou R, Dai W, Yao Y, Liu Y, Sun T, Shen J, An S, Yan L, Zhang H, Leng X, Ding Z.   +11 more
europepmc   +1 more source

Central 43 RFamide peptide (QRFP43) administration modulates microbial activity and fatty acid biohydrogenation in the ovine digestive tract. [PDF]

Sci Rep
Wojtak W, Białek M, Białek A, Czauderna M, Kowalik B, Majewska MP, Przybył BJ.   +6 more
europepmc   +1 more source

Integrated Experimental and Computational Investigation of Azobenzenoid Derivatives Against Trypanosomatid: RNA Editing Ligase 1 as a Potential Molecular Target. [PDF]

Acta Parasitol
Khan A, Balbinot RB, Lazarin-Bidóia D, Paetzold MG, Seixas ÍN, Ramos Silva GN, Fernandez MA, Nakamura CV, Seixas FAV.   +8 more
europepmc   +1 more source

The biology of the Protozoa

, 1926
openaire   +3 more sources

The Framework of Host Innate and Adaptive Immunological Pathways. [PDF]

Biomedicines
Hu WC.
europepmc   +1 more source

A curated database of rumen ciliate protozoal 18S rRNA gene sequences for metataxonomic applications. [PDF]

BMC Genom Data
Lawther K, Tapio I, Vera-Ponce de León A, Aho VTE, Huws SA, Dimonaco NJ.   +5 more
europepmc   +1 more source

Lower prevalence of Blastocystis spp. and Dientamoeba fragilis in ulcerative colitis and association with disease activity. [PDF]

Eur J Clin Microbiol Infect Dis
Bénard MV, Zonneveld R, Haaften PB, Wentink-Bonnema EMS, Matamoros S, Ponsioen CY.   +5 more
europepmc   +1 more source