Results 31 to 40 of about 37,755 (213)

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie International Edition, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +1 more source

The National External Quality Assessment Scheme for Diagnostic Medical Parasitology in the Philippines, 2009–2015

Philippine Journal of Pathology, 2019
OBJECTIVE               The Research Institute for Tropical Medicine (RITM)–National Reference Laboratory (NRL) for Malaria and Other Parasites, mandated by the Department of Health–Philippines (DOH), administers an annual Proficiency Test (PT) in ...
Sherwin Galit, Dave Tangcalagan, Julius Matt Rapanut, Alexander Sadiasa, Prince Ninja Bautista, Kim Joshua Dominguez, Jahra Bañaga, Celine Bernice Roxas, Rafael Navarro, Mark Philip Bugayong, Jennifer Luchavez, Melisa Mondoy, Lydia Sombrero, Socorro Lupisan   +13 more
doaj   +1 more source

Protozoan infection in archaeological material

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, 1970
The identification of parasites in ancient human feces is compromised by differential preservation of identifiable parasite structures. However, protein molecules can survive the damage of the environment. It was possible to detected antigen of Entamoeba histolytica and Giardia duodenalis in historic and prehistoric human fecal remains using two enzyme
Gonçalves, Marcelo L.C., Schnell, C., Sianto, Luciana, Le Bailly, Matthieu, Reinhard, Karl J., Bouchet, Françoise, Ferreira, Luiz Fernando, Araujo, Adauto   +7 more
openaire   +3 more sources

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Detection of enteric parasite DNA in household and bed dust samples: potential for infection transmission. [PDF]

, 2020
BACKGROUND: Enteric parasites are transmitted in households but few studies have sampled inside households for parasites and none have used sensitive molecular methods.
Calderón, E, Cooper, PJ, Garcia-Ramon, D, Lopez, A, Mejia, R, Seco-Hidalgo, V   +5 more
core   +1 more source

Enemy release: loss of parasites in invasive freshwater bivalves Sinanodonta woodiana and Corbicula fluminea

Ecography, EarlyView.
Invasive freshwater bivalves harm native species, ecosystems and biodiversity, and incur economic costs. The enemy release hypothesis posits that invasive species are released from enemies during the invasion process, giving them a competitive advantage in the new environment.
Binglin Deng, Nicoletta Riccardi, Pin Nie, Maria Urbańska, Timo J. Marjomäki, Wojciech Andrzejewski, Małgorzata Ożgo, Keiko Nakamura, Jouni Taskinen   +8 more
wiley   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon.

PLoS Neglected Tropical Diseases, 2016
BackgroundIntestinal protozoan infections are confirmed as major causes of diarrhea, particularly in children, and represent a significant, but often neglected, threat to public health.
Marwan Osman, Dima El Safadi, Amandine Cian, Sadia Benamrouz, Céline Nourrisson, Philippe Poirier, Bruno Pereira, Romy Razakandrainibe, Anthony Pinon, Céline Lambert, Ivan Wawrzyniak, Fouad Dabboussi, Frederic Delbac, Loïc Favennec, Monzer Hamze, Eric Viscogliosi, Gabriela Certad   +16 more
doaj   +1 more source

Testing of Geat Bay Oysters for Two Protozoan Pathogens [PDF]

, 2014
Two protozoan pathogens, Haplosporidium nelsoni (MSX) and Perkinsus marinus (Dermo), are known to be present in Great Bay oysters. With funds provided by the Piscataqua Region Estuaries Partnership (PREP), the Marine Fisheries Division of the New ...
Grout, Douglas E.
core   +2 more sources

Equine trypanosomiasis, a systematic review: Disease management

Equine Veterinary Journal, EarlyView.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design Systematic review.
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David Sutton   +5 more
wiley   +1 more source