Results 151 to 160 of about 71,120 (247)

Translational Pharmacokinetic‐Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI‐6148 for the Treatment of Cutaneous Leishmaniasis

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Cutaneous leishmaniasis is a neglected tropical disease with only one oral treatment option. DNDI‐6148 is an orally bioavailable compound with potent antiparasitic activity in preclinical studies. Establishing skin target‐site pharmacokinetic/pharmacodynamic (PK/PD) relationships is essential to enable its clinical development.
Rasmus Hansen Henninger, Wietse M. Schouten, Byron Arana, Jean‐Yves Gillon, Charles E. Mowbray, Jadel Müller Kratz, Katrien Van Bocxlaer, Thomas P. C. Dorlo   +7 more
wiley   +1 more source

Environmental Effects on the Selective Feeding and Fatty Acid Retention of Freshwater Pearl Mussel

Freshwater Biology, Volume 71, Issue 4, April 2026.
ABSTRACT Land‐use activities within catchments alter surface runoff dynamics, potentially influencing food quality and quantity available to consumers. Essential fatty acids are crucial biomolecules for consumers, which they usually need to uptake from their diet.
Mahsa Hajisafarali, Marco L. Calderini, Mikko Kiljunen, Niklas Moser, Sabrina Nykänen, Jaakko J. Litmanen, Sami Taipale, Jouni Taskinen   +7 more
wiley   +1 more source

Looking for Greener Pastures: In Vitro Screening of Phytogenics for the Control of Sparicotyle chrysophrii in Gilthead Sea Bream

Journal of Fish Diseases, Volume 49, Issue 4, April 2026.
ABSTRACT The gill parasite Sparicotyle chrysophrii poses a significant threat to gilthead sea bream (Sparus aurata) aquaculture in the Mediterranean, causing considerable mortality and economic losses. As traditional chemotherapeutic treatments, like formalin, face growing regulatory restrictions, there is an urgent need for alternative control ...
Teresa Pirollo, Ana León, Monica Caffara, Alice Caneschi, Itziar Estensoro, Jinni Gu, Maurizio Scozzoli, Ariadna Sitjà‐Bobadilla, Oswaldo Palenzuela   +8 more
wiley   +1 more source

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL‐6, TNF‐α and IL‐10 Expression in Canine Macrophages Infected With Leishmania infantum

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT Zoonotic visceral leishmaniasis is caused by Leishmania (Leishmania) infantum. Dogs are considered the most critical urban reservoirs of L. (L.) infantum due to their high infection rate and direct transmission to humans. The parasite has developed mechanisms to evade the host's defence system by inhibiting macrophage activation, thereby ...
Gabriela Lovizutto Venturin, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Gabriela Torres Rebech, Flávia Lombardi Lopes, Valéria Marçal Felix de Lima   +5 more
wiley   +1 more source

Endocrine Disruptive Effects of the Herbicides Linuron, Chloridazon and Metribuzin on Bovine Granulosa Cells

Reproduction in Domestic Animals, Volume 61, Issue 4, April 2026.
ABSTRACT Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen (E2) and progesterone (P4) secretion in vitro.
Metehan Eser Kahveci, Ayse Arzu Yigit, Ruhi Kabakci   +2 more
wiley   +1 more source

Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Gonzalo Vílchez‐Pinto, María Garrido‐Arandia, Antonio Molina, Miguel Ángel Torres, Lucía Jordá   +4 more
wiley   +1 more source

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Crossed Erythrocytes Agglutination Pattern Observed in a Patient With Hereditary Elliptocytosis

International Journal of Laboratory Hematology, Volume 48, Issue 2, Page 240-241, April 2026.
Márcio A. W. Melo, Cristina M. Silveira, Maíra M. Ribeiro, Gabriela S. Arcanjo   +3 more
wiley   +1 more source

First Step Towards the Humanisation of Protein N‐Glycosylation in Chlamydomonas reinhardtii Through Heterologous Expression of α(1,2)‐Mannosidases

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2698-2700, April 2026.
C. Plasson, J. Balieu, P. Lerouge, M. Bardor, E. Mathieu‐Rivet   +4 more
wiley   +1 more source

The cytoskeleton of pathogenic protists. [PDF]

Biosci Rep
de Souza W, Gadelha AP, Benchimol M.
europepmc   +1 more source