Results 71 to 80 of about 7,935 (286)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Forced Migration Review, 2009 The way that mobility is dealt with in respect of protractedrefugee situations shows a gap between social practices andinternational policies.
Giulia Scalettaris
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Europe’s IDPs still marginalised [PDF]
Forced Migration Review, 2009 To bring an end to displacement for some 2.5 million IDPsin Europe, governments’ focus on return must be broadenedto include support and assistance for local integration andsettlement elsewhere in the country.
Nadine Walicki
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Rights Displaced: The Effects of Long-term Encampment on the Human Rights of Refugees [PDF]
This paper investigates the use of long-term encampment policies in protracted refugee situations. Unlike most contemporary scholarship on the subject, this work focuses on the human rights of encamped refugees rather than on their rights under ...
Sytnik, Svetlana
core
Repatriation to Afghanistan: durable solution or responsibility shifting? [PDF]
Forced Migration Review, 2009 Despite the return of almost five million Afghan refugeesto Afghanistan since 2002, about three million still remainabroad. What are their prospects of return? More to the point,what is the prospect of those who have returned remainingin Afghanistan?
Susanne Schmeidl
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Emotional Vulnerability of Displaced Children in a Protracted Conflict
Artha - Journal of Social Sciences, 2019 Children are the most vulnerable and affected population in areas of protracted armed conflict. Due to internal displacement, deaths, injury, separation from family, and other social and economic disruptions are on the rise. In India, there are limited studies focussing on children in protracted conflict. This study focusses on the state of Manipur and
Grace K, Neinunnem +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source