Results 71 to 80 of about 218,319 (295)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason   +12 more
wiley   +1 more source

EFFECTS OF FLOW ROUTING PLATE ON MIXED CONVECTION HEAT TRANSFER FROM PROTRUDED HEAT SOURCES

open access: yes, 2016
In this study, the effect of the flow routing plates on the laminar mixed convection heat transfer in a horizontal channel that has protruded heat sources at the bottom and top surfaces were investigated numerically and experimentally. The air was used as the cooling fluid, and protruded heat sources were equipped as 4x8 rows into the rectangle channel
KURŞUN, Burak, SİVRİOĞLU, Mecit
openaire   +4 more sources

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu   +15 more
wiley   +1 more source

Pioneer Venus large probe neutral mass spectrometer [PDF]

open access: yes
The deuterium hydrogen abundance ratio in the Venus atmosphere was measured while the inlets to the Pioneer Venus large probe mass spectrometer were coated with sulfuric acid from Venus' clouds.
Hoffman, J.
core   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

open access: yesAdvanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin   +2 more
wiley   +1 more source

Mandibular Advancement Device (MAD) for Obstructive Sleep Apnea in an Edentulous Patient. [PDF]

open access: yesCureus, 2022
Burugpalli A   +5 more
europepmc   +1 more source

Influence of various fabrication methods on the compressive strength of titanium skin- stringer panels [PDF]

open access: yes
Influence of fabrication methods on compressive strength of titanium alloy skin stringer ...
Gardner, J. E.   +2 more
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

open access: yesAdvanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun   +13 more
wiley   +1 more source

2D parallel optical interconnects between CMOS ICs [PDF]

open access: yes, 2006
ANNEN, R   +7 more
core   +2 more sources

Home - About - Disclaimer - Privacy