Results 11 to 20 of about 220,158 (213)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Pyroxene-rich Orange sand highway from basaltic highlands to the ocean: Modern sediment-routing system of an Early Jurassic river

Geosystems and Geoenvironment
Studying the origin of rivers, the development of drainage through geological time, and the multiple processes that affect the composition of the sediment is a fascinating scientific adventure. This article probes into modern sedimentary processes in the
Eduardo Garzanti, Guido Pastore, Sergio Andò, Marta Barbarano, Alberto Resentini, Giovanni Vezzoli, Pieter Vermeesch, Pedro Dinis, Annette Hahn, Errol Wiles, Lindani Ncube, Helena-Johanna Van Niekerk   +11 more
doaj   +1 more source

Physics‐Grounded Materials Artificial Intelligence for Reliable Materials Discovery

Advanced Functional Materials, EarlyView.
Physics‐Grounded Materials AI (PhysMat AI) integrates physical priors, descriptors, constraints, verification, and data infrastructure into a unified full‐stack framework, enabling reliable, interpretable, and autonomous AI‐driven materials discovery.
Yuhang Wang, Qian Wang, Seong‐Hoon Jang, Hao Li   +3 more
wiley   +1 more source

A Model To Capture Interaction Between Data Provenance And Workflow Provenance

JISR on Computing, 2014
Provenance means origin. There are two types of Provenance namely Data Provenance and Workflow Provenance. Data Provenance refers to the process of recording and tracking the source or origin of data while workflow provenance means history of workflows ...
Zeeshan Ahmed, Syed Saif ur Rahman
doaj   +1 more source

Aggregation by Provenance Types: A Technique for Summarising Provenance Graphs [PDF]

Electronic Proceedings in Theoretical Computer Science, 2015
As users become confronted with a deluge of provenance data, dedicated techniques are required to make sense of this kind of information. We present Aggregation by Provenance Types, a provenance graph analysis that is capable of generating provenance ...
Luc Moreau
doaj   +1 more source

Bio‐Inspired Multifunctional Superhydrophilic Coatings With Remarkably Fast Self‐Healing Abilities

Advanced Functional Materials, EarlyView.
We developed bio‐inspired multifunctional hydrogel‐based coatings that exhibit extremely fast/repeatable self‐healing abilities, long‐lasting anti‐fogging performance, superhydrophilicity in air, and underwater superoleophobicity. By doping multivalent metal‐ions into the hydrogel networks, which promoted hydrogen bonding formation and enhanced the ...
Hyeonjin Kim, Jerred Wassgren, Hiroshi Kakiuchida, Kouki Akaike, Shunsuke Tanaka, Atsushi Hozumi   +5 more
wiley   +1 more source

Morphological traits of Scots pine (Pinus sylvestris L.) in international provenance tests in Bosnia and Herzegovina

Acta Silvae et Ligni, 2020
Scots pine (Pinus sylvestris L.) is one of the most important tree species in European forests. This study aims to determine whether there is inter-provenance variability in researched morphological traits in two international provenance tests of Scots ...
Mirzeta Memišević Hodžić, Semir Bejtić, Selma Vejzagić, Dalibor Ballian   +3 more
doaj   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source

Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines

OncoImmunology, 2019
The humanized immunocytokine, hu14.18-IL2 (ICp), leads to the immune cell-mediated destruction of GD2-expressing tumors in mouse models, resulting in potent antitumor effects with negligible IL2-related toxicity. In contrast, when ICp is used clinically,
Zulmarie Perez Horta, Swetha Saseedhar, Alexander L. Rakhmilevich, Lakeesha Carmichael, Jacquelyn A. Hank, Margaret Boyden, Stephen D. Gillies, Paul M. Sondel   +7 more
doaj   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source