Results 151 to 160 of about 3,151,292 (307)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A meta-analysis of genome-wide association studies identifies multiple longevity genes [PDF]

, 2019
al., et, Province, Michael A., Wojczynski, Mary K.   +2 more
core   +1 more source

Retraction Note: circGIGYF1 inhibits stemness and metastasis in colorectal cancer by promoting WWP2-HOXD13 interaction to regulate β-catenin signalling. [PDF]

Commun Biol
Zhao B, Li J, Wang Z, Zhou H, Cheng Z, Ma S.   +5 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function [PDF]

, 2018
Feitosa, Mary F., Province, Michael A., Wojczynski, Mary K.   +2 more
core   +1 more source

The influence of extreme rainfall on crime: Spatiotemporal dynamics in Hunan Province, China. [PDF]

PLoS One
Zhang D, Xiao Y, Han Y, Li T, Li X, Chen X, Fang J, Zhong P, Ning Z.   +8 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Correction: Abnormalities of brain gray matter in bipolar depression and unipolar depression. [PDF]

Front Psychol
Zhou L, Wu G, Li X, Liu C.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Epidemiological characteristics of brucellosis in non-occupational population in Zhejiang Province, China, 2018-2024: epidemic trend and infection analysis. [PDF]

One Health Outlook
Shi X, Yang Y, Liu Y, Ren J, Zhang R, Guo S, Ma H, Sun J.   +7 more
europepmc   +1 more source