Results 161 to 170 of about 941,388 (311)

An inventory of undiscovered Canadian mineral resources [PDF]

Unit regional value (URV) and unit regional weight are area standardized measures of the expected value and quantity, respectively, of the mineral resources of a region.
Griffiths, J. C., Labovitz, M. L.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enhancing Alzheimer's Disease and Related Dementia Burden Projections and Policy Targeting in China. [PDF]

Health Data Sci
Liu C.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Conference Report on the 2025 Annual Review of the Essential Programme on Immunization in DR Congo: Dealing with Complexity. [PDF]

Vaccines (Basel)
Mulumba A, Mboussou F, Nasaka P, Byamwitenga AM, Cikomola A, Nogier C, Gaha TN, Mwika M, Nguimbis BT, Farham B, Ancia A, Impouma B.   +11 more
europepmc   +1 more source

An Evaluation of the Risk-Sharing Function of Equalization in Canada [PDF]

The Canadian system of equalization is designed to address differences in revenue-raising capacity across provinces, basing entitlements on actual provincial tax rates and bases.
Masayoshi Hayashi, Robin Boadway
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Cross-sectional study on the current status of county-level cancer prevention and treatment capabilities in the four southwestern provinces of China. [PDF]

Front Public Health
Tan X, Du C, Cai H, Xu J, Zhang Y, Li Y, Lin H, Li C, Liang H, Xiang X.   +9 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Real-time digital prescriptions unlock influenza dynamics: evidence from 21 million transactions. [PDF]

NPJ Digit Med
Shen R, Xu X, Yang L, Wang Z, Yang R, Liu X, Xu Z, Jiang H, Sun N, Wang D, Liu H, Feng L.   +11 more
europepmc   +1 more source