FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Provincial Trends in Childhood Vaccine Coverage in Afghanistan From 2000 to 2024: An Ecological Study of Findings From the Institute for Health Metrics and Evaluation. [PDF]
CureusKhan A, Tidman M.
europepmc +1 more source
The Impact of Interprovincial Migration on Aggregate Output and Labour Productivity in Canada, 1987-2006 [PDF]
The Impact of Interprovincial Migration on Aggregate Output and Labour Productivity in Canada, 1987-2006Interprovincial migration has increased significantly in Canada since 2003.
Daniel Ershov +2 more
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Survey on the current status of rabies post-exposure prophylaxis clinics construction and the surveillance of rabies-exposed individuals in China, 2022. [PDF]
PLoS Negl Trop DisRen Q +10 more
europepmc +1 more source
Revue illustrée des provinces de l'Ouest / dir. L. Séché
, 1890 Variante(s) de titre : Revue des provinces de l'OuestPériodicité : MensuelEtat de collection : 1891/09 (A7,T5) --> 1891/12 à 1998 (A14,T22)
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Geographical disparities and programmatic determinants of hydrocele surgery and lymphoedema management coverage for lymphatic filariasis in the Democratic Republic of the Congo, 2018-2024: A national analysis of routine programme data. [PDF]
PLoS Negl Trop DisMakenga Bof JC, Muteba D.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Occurrence of Antimicrobial-Resistant <i>Listeria monocytogenes</i> and <i>Listeria</i> spp. Recovered From Cattle Farms and the Factors Associated With Their Distribution in Mpumalanga and North West Provinces in South Africa. [PDF]
Vet Med IntMoabelo KC +5 more
europepmc +1 more source