Results 191 to 200 of about 440,698 (315)

Impact Assessment of Spatial Mismatch Between Grain Production and Consumption on Non-Point Source Pollution and Carbon Emissions from Grain Production in China. [PDF]

Foods
Yang H, Sieber S.
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

National, Subnational, and Risk-Attributed Burden of Chronic Respiratory Diseases in Iran (1990-2021): A Longitudinal Clustering Analysis of Global Burden of Disease 2021 Data. [PDF]

Health Sci Rep
Loeloe MS, Tabatabaei SM, Sefidkar R, Mehrparvar AH, Jambarsang S.   +4 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Protocol for Identifying Priorities for Women+ Health in the Maritime Provinces Using a Priority Setting Partnership Approach. [PDF]

Healthcare (Basel)
Dol J, Pritchett C, Larocque L, Bentley J, Brooks M, Rose AJE, Rosen NO, Davies E, Yeluri M, Gosse M.   +9 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Provincial inequalities in child nutritional risk: a public health multivariate approach using Z-score matrices for spatial vulnerability assessment. [PDF]

Front Public Health
Morán-Herrera AA, Idrovo-Hurel MM, Sandoval-Tamayo VP, Reyes-Durango JN, Peralta-Gamboa DA.   +4 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Provincial variability in congenital heart disease prevalence in Argentina, 2014-2019: A population-based analysis from national registry data. [PDF]

PLOS Glob Public Health
Vita MC, Fantozzi N, Méndez Ortiz F, Di Lullo L, Kokal R, Peralta S, Di Lalla S.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source