Results 71 to 80 of about 363,972 (316)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Analysis of GDP trends and inequalities in Vietnam’s provinces and groups of provinces

open access: yes, 2016
Article is also free to read on publisher website.\ud \ud Our recent paper (Vu et al., 2016) applied the Phillips and Sul’s\ud method (2007, 2009) and found that the 61 provinces of Vietnam\ud were formed in five convergence sub-groups.
Nghiem, Son   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mithracinae (Decapoda: Brachyura) from the Brazilian coast: review of the geographical distribution and comments on the biogeography of the group

open access: yesNauplius
The geographical distribution of marine organisms, as a result of complex natural processes through geological time, has been changed, sometimes drastically, by species introductions.
Douglas Fernandes Rodrigues Alves   +3 more
doaj  

FDI convergence and Spatial Dependence between Chinese Provinces [PDF]

open access: yes
This study aims at investigating the spatial dimension of the FDI. Considering the distribution of FDI between the provinces, our purpose is the spatial dependency that may be observed.
Mary-Françoise RENARD   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gobernanza electoralen unidades subnacionalesde Bolivia y Argentina:un análisis desde los procesos de empadronamiento / Electoral Governance in Bolivia and Argentina’sSub-national Units: An Analysis of Voter Registration

open access: yesRevista del Instituto Electoral del Estado de México. Apuntes Electorales, 2017
El presente artículo tiene como objeto el estudio de una función considerada fundamental dentro del amplio proceso de la organización y la admi-nistración de las elecciones: el empadronamiento electoral.
Julio Alejandro Ascarrunz Medinaceli   +1 more
doaj  

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