Results 121 to 130 of about 3,357,686 (245)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The framework for inspecting residential provision in further education colleges : for use from September 2012 [PDF]
, 2012 "This document sets out the framework for the inspection of residential provision in further education colleges in England. It should be read alongside the Evaluation schedule for the inspection of residential provision in further education colleges ...
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Asylum Policy under New Labour [PDF]
, 2005 This article examines New Labour policies on asylum with a focus on changes in welfare provision. The changes that have taken place have resulted in the exclusion of asylum seekers from 'mainstream' provision and have led to an increase in poverty and ...
Bloch, A., Schuster, L.
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
WHY AND HOW SHOULD THE GOVERNMENT FINANCE PUBLIC GOODS IN RURAL AREAS? A REVIEW OF ARGUMENTS [PDF]
This paper reviews three arguments why government should not directly finance public goods provision in the countryside: (1) sorting and voting of residents leads to efficient local public goods provision, (2) community governance may better cope with ...
Petrick, Martin
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Do clubs foster provision success ? [PDF]
We report the results of an experiment on the provision of a step-level collective good. We compare subjects’ behavior in a public good game and in a club good game.
Marc Willinger, Mohamed Ali Bchir
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Quality provision under referral consumption [PDF]
I analyze incentives for provision of quality in a market for an experience good. There is a single producer who is choosing quality and price taking into account three features.
Noemí Navarro
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